Intracranial atherosclerosis
Intracranial atherosclerosis
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DOI：
10.1016/s0140-6736(13)61088-0
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发表时间：
2014-03-15
期刊：
影响因子：
168.9
通讯作者：
Caplan, Louis R.
中科院分区：
文献类型：
--
作者：
Qureshi, Adnan I.;Caplan, Louis R.
动脉粥样硬化性疾病通常累及颅内动脉，包括那些被颅骨和硬脑膜包裹的动脉，以及那些位于蛛网膜下腔的动脉。年龄、高血压和糖尿病是颅内动脉粥样硬化的独立危险因素。颅内动脉粥样硬化可导致血栓栓塞症，并伴有或不伴有低灌注，从而导致短暂或永久性的脑缺血事件。缺血性中风和其他心血管事件的高复发率要求及早诊断和治疗。目前的治疗是基于抗血小板药物的组合，优化血压和低密度脂蛋白胆固醇值，以及在选定的患者中进行颅内血管成形术或支架植入，或两者兼而有之。
Atherosclerotic disease often involves the intracranial arteries including those encased by cranial bones and dura, and those located in the subarachnoid space. Age, hypertension, and diabetes mellitus are independent risk factors for intracranial atherosclerosis. Intracranial atherosclerosis can result in thromboembolism with or without hypoperfusion leading to transient or permanent cerebral ischaemic events. High rates of recurrent ischaemic stroke and other cardiovascular events mandate early diagnosis and treatment. Present treatment is based on a combination of antiplatelet drugs, optimisation of blood pressure and LDL cholesterol values, and intracranial angioplasty or stent placement, or both, in selected patients.