Alterations of the PPP2R1B gene in human lung and colon cancer
Alterations of the PPP2R1B gene in human lung and colon cancer
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DOI：
10.1126/science.282.5387.284
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发表时间：
1998-10-09
期刊：
影响因子：
56.9
通讯作者：
Evans, GA
中科院分区：
文献类型：
--
作者：
Wang, SS;Esplin, ED;Evans, GA
The PPP2R1B gene, which encodes the beta isoform of the A subunit of the serine/threonine protein phosphatase ZA (PP2A), was identified as a putative human tumor suppressor gene. Sequencing of the PPP2R1B gene, located on human chromosome 11q22-24, revealed somatic alterations in 15% (5 out of 33) of primary lung tumors, 6% (4 out of 70) of lung tumor-derived cell lines, and 15% (2 out of 13) of primary colon tumors. One deletion mutation generated a truncated PP2A-A beta protein that was unable to bind to the catalytic subunit of the PP2A holoenzyme. The PP2R1B gene product may suppress tumor development through its role in cell cycle regulation and cellular growth control.
