Marked prolongation of porcine renal xenograft survival in baboons through the use of α1,3-galactosyltransferase gene-knockout donors and the cotransplantation of vascularized thymic tissue
Marked prolongation of porcine renal xenograft survival in baboons through the use of α1,3-galactosyltransferase gene-knockout donors and the cotransplantation of vascularized thymic tissue
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DOI：
10.1038/nm1172
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发表时间：
2005-01-01
期刊：
影响因子：
82.9
通讯作者：
Sachs, DH
中科院分区：
文献类型：
--
作者：
Yamada, K;Yazawa, K;Sachs, DH
动物器官的使用可能会缓解世界范围内临床移植供体器官的严重短缺。由于对异种移植物的强烈免疫应答，成功将可能取决于免疫抑制和诱导耐受的新策略。在这里，我们报告我们的初步结果，使用α-1，3-半乳糖基转移酶敲除（GalT-KO）供体和耐受诱导方法。我们已经实现了维持生命的猪到狒狒异种肾移植存活长达83天，肌酐水平正常。
The use of animal organs could potentially alleviate the critical worldwide shortage of donor organs for clinical transplantation. Because of the strong immune response to xenografts, success will probably depend upon new strategies of immune suppression and induction of tolerance. Here we report our initial results using alpha-1,3-galactosyltransferase knockout (GalT-KO) donors and a tolerance induction approach. We have achieved life-supporting pig-to-baboon renal xenograft survivals of up to 83 d with normal creatinine levels.