ApoE mimetic peptide reduces plasma lipid hydroperoxide content with a concomitant increase in HDL paraoxonase activity.
ApoE mimetic peptide reduces plasma lipid hydroperoxide content with a concomitant increase in HDL paraoxonase activity.
复制标题
ApoE 模拟肽降低血浆脂质氢过氧化物含量，同时增加 HDL 对氧磷酶活性。
DOI：
10.1007/978-1-60761-350-3_1
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发表时间：
2010
影响因子：
--
通讯作者：
Anantharamaiah,GM
中科院分区：
文献类型：
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作者：
Datta,Geeta;Chaddha,Manjula;Handattu,ShailaP;Palgunachari,MayakondaN;Nayyar,Gaurav;Garber,DavidW;Gupta,Himanshu;White,CRoger;Anantharamaiah,GM
ApoE mimetic peptide possesses the putative receptor binding domain 141–150 (LRKLRKRLLR) of apoE covalently linked to the class A amphipathic helical peptide 18A. It dramatically reduces plasma cholesterol in dyslipidemic mouse and rabbit models. Recycling of apoE mimetic peptide increases the duration of preβ-HDL formation leading to extended anti-inflammatory and atheroprotective properties.
