Intensity-based statistical scorer for tandem mass spectrometry
Intensity-based statistical scorer for tandem mass spectrometry
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DOI：
10.1021/ac0258913
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发表时间：
2003-02-01
影响因子：
7.4
通讯作者：
Smilansky, Z
中科院分区：
文献类型：
--
作者：
Havilio, M;Haddad, Y;Smilansky, Z
我们描述了一个新的统计评分器串联质谱。评分器是基于具有给定化学性质的碎片在实验光谱中产生测量强度水平的概率。记分员的参数使用全自动程序计算。基准的一个大的实验光谱的新评分器，我们表明，它的表现显着优于广泛使用的互相关评分算法的Eng等人。
We describe a new statistical scorer for tandem mass spectrometry. The scorer is based on the probability that fragments with given chemical properties create measured intensity levels in the experimental spectrum. The scorer's parameters are computed using a fully automated procedure. Benchmarking the new scorer on a large set of experimental spectra, we show that it performs significantly better than the widely used cross-correlation scoring algorithm of Eng et al.