Lymphopenia-driven CD8(+) T cells are resistant to antigen-induced tolerance in NOD.scid mice.
Lymphopenia-driven CD8(+) T cells are resistant to antigen-induced tolerance in NOD.scid mice.
复制标题
NOD.scid 小鼠中淋巴细胞减少驱动的 CD8(+) T 细胞对抗原诱导的耐受具有抵抗力。
DOI：
10.1002/eji.200535717
复制
发表时间：
2006
期刊：
影响因子：
--
通讯作者：
Tisch,Roland
中科院分区：
文献类型：
--
作者：
Long,Brian;Wong,CarmenP;Wang,Yaming;Tisch,Roland
T cells undergoing lymphopenia‐driven proliferation acquire effector and memory properties that can be pathogenic. Indeed, generalized lymphopenia is associated with a variety of autoimmune diseases such as type 1 diabetes. The current study was carried out to determine how CD8+T cells undergoing acute lymphopenic expansion respond to antigen under tolerizing conditionsin vivo. Adoptive transfer of diabetes by TCR‐transgenic CD8+T cells was enhanced following treatment of NOD.scidrecipients with a high dose of soluble peptide. Furthermore, whereas TCR‐transgenic CD8+T cells underwent clonal deletion and failed to differentiate into CTL in peptide‐treated lymphoreplete recipient mice, TCR‐transgenic CD8+T cells in a lymphopenic environment were resistant to clonal deletion, and CTL differentiation was enhanced by a high dose of soluble peptide. Moreover, peptide treatment had distinct effects on expression of the anti‐apoptotic protein Bcl‐XLin TCR‐transgenic CD8+T cells under lymphopenicversuslymphoreplete conditions. These results demonstrate that CD8+T cells undergoing lymphopenia‐driven expansion in NOD.scidrecipients are resistant to antigen‐induced tolerance, and readily differentiate into CTL upon stimulation with a high dose of soluble peptide.
