REPRODUCTIVE TOXICOLOGY: Pregnancy exposure to endocrine disrupting chemicals: implications for women's health.
REPRODUCTIVE TOXICOLOGY: Pregnancy exposure to endocrine disrupting chemicals: implications for women's health.
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生殖毒理学：妊娠期暴露于内分泌干扰化学品：对妇女健康的影响。
DOI：
10.1530/rep-21-0051
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发表时间：
2021-10-07
期刊：
影响因子：
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通讯作者：
Strakovsky RS
中科院分区：
文献类型：
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作者：
Haggerty DK;Upson K;Pacyga DC;Franko JE;Braun JM;Strakovsky RS
女性普遍暴露于食品接触材料和个人护理产品中的非持久性内分泌干扰物（EDCs）。了解接触这些化学物质对女性怀孕和长期健康结果的影响是一个重要的研究领域，但在很大程度上被忽视了。这篇简短的综述集中在探索非持久性内分泌干扰物（包括邻苯二甲酸酯、对羟基苯甲酸酯、双酚和三氯生）与孕产妇妊娠结局和女性长期健康结局之间关系的流行病学文献上。我们专注于这项研究的挑战，特别是评估非持续性EDC暴露，研究设计和分析方面。最后，我们回顾了非持续性EDC研究的最佳实践与怀孕和妇女的健康。虽然有限，但我们发现一些证据表明，接触非持久性内分泌干扰物与怀孕健康有关。然而，这些研究的结果并不一致，需要加以证实。最近的研究还提出，妊娠期非持续性EDC暴露可能会对产后孕产妇健康产生不利影响。到目前为止，只有少数研究已经进行，并只集中在产后体重。需要在这一领域开展更多的研究，为促进妇女一生最佳健康的努力提供信息。
Women are ubiquitously exposed to non-persistent endocrine disrupting chemicals (EDCs) from food contact materials and personal care products. Understanding the impacts of exposure to these chemicals on pregnancy and long-term health outcomes in women is a critical area of research that has been largely overlooked. This brief review focuses on the epidemiological literature exploring associations of non-persistent EDCs – including phthalates, parabens, bisphenols, and triclosan – with maternal pregnancy outcomes and long-term health outcomes in women. We focus on the challenges of this research, particularly assessing non-persistent EDC exposures, aspects of study design, and analyses. We conclude by reviewing the best practices for non-persistent EDC research with regards to pregnancy and women’s health. Though limited, we found some evidence indicating that exposure to non-persistent EDCs is associated with pregnancy health. However, findings from these studies have been inconsistent and require corroboration. Recent studies have also proposed that non-persistent EDC exposures in pregnancy may adversely affect postnatal maternal health. To date, only a few studies have been conducted and have only focused on postpartum weight. More research is needed in this area to inform efforts to promote optimal health across the lifespan of women.