Disrupted Balance of Long- and Short-Range Functional Connectivity Density in Type 2 Diabetes Mellitus: A Resting-State fMRI Study
Disrupted Balance of Long- and Short-Range Functional Connectivity Density in Type 2 Diabetes Mellitus: A Resting-State fMRI Study
复制标题
2 型糖尿病中长程和短程功能连接密度的平衡被破坏：一项静息态 fMRI 研究。
DOI：
10.3389/fnins.2018.00875
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发表时间：
2018-11-27
影响因子：
4.3
通讯作者：
Wang, Jian
中科院分区：
文献类型：
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作者：
Liu, Daihong;Chen, Lihua;Wang, Jian
先前的研究表明，2型糖尿病（T2DM）可以加速患者认知能力下降的速度。脑网络作为一个高能量消耗的器官，在低能量消耗和高信息传递效率之间取得平衡。然而，T2DM可能会改变短距离和远程连接的比例，以适应能量供应不足，并在脑糖代谢稳态改变引起的能量压力下应对各种认知任务。在上述理论的基础上，本研究利用静息状态功能磁共振成像（fMRI）数据，对32例T2DM患者与32例健康对照（HC）的脑功能连接进行了长程和短程功能连接密度（FCD）分析。这些患者的认知功能水平也通过神经心理测试进行评估。研究T2DM患者FCD异常特征及其与认知功能障碍的关系。与HC组比较，T2DM患者左脑胼胝体和左舌回远端FCD减少，右角回和左额上回内侧近端FCD增加（p < 0.05，高斯随机场理论校正）。T2DM患者左侧额上回内侧部分FCD z得分与轨迹测试B部分时间成本呈负相关（rho = 0.422, p = 0.018）。此外，右角回FCD z分数与听觉言语学习测验的长期延迟回忆分数呈负相关（rho= 0.356, p = 0.049），与数字跨距测验的前向分数呈负相关（rho= 0.373, p = 0.039）。T2DM患者表现出异常的远程和近程FCD模式，这可能提示大脑网络重组以失去远程FCD整合为代价以适应能量供应不足。这些变化可能与2型糖尿病患者的认知能力下降有关。
Previous studies have shown that type 2 diabetes mellitus (T2DM) can accelerate the rate of cognitive decline in patients. As an organ with high energy consumption, the brain network balances between lower energy consumption and higher information transmission efficiency. However, T2DM may modify the proportion of short- and long-range connections to adapt to the inadequate energy supply and to respond to various cognitive tasks under the energy pressure caused by homeostasis alterations in brain glucose metabolism. On the basis of the above theories, this study determined the abnormal functional connections of the brain in 32 T2DM patients compared with 32 healthy control (HC) subjects using long- and short-range functional connectivity density (FCD) analyses with resting-state fMRI data. The cognitive function level in these patients was also evaluated by neuropsychological tests. Moreover, the characteristics of abnormal FCD and their relationships with cognitive impairment were investigated in T2DM patients. Compared with the HC group, T2DM patients exhibited decreased long-range FCD in the left calcarine and left lingual gyrus and increased short-range FCD in the right angular gyrus and medial part of the left superior frontal gyrus (p < 0.05, Gaussian random-field theory corrected). In T2DM patients, the FCD z scores of the medial part of the left superior frontal gyrus were negatively correlated with the time cost in part B of the Trail Making Test (rho = 0.422, p = 0.018). In addition, the FCD z scores of the right angular gyrus were negatively correlated with the long-term delayed recall scores of the Auditory Verbal Learning Test (rho = 0.356, p = 0.049) and the forward scores of the Digital Span Test (rho= 0.373, p = 0.039). T2DM patients exhibited aberrant long-range and short-range FCD patterns, which may suggest brain network reorganization at the expense of losing the integration of long-range FCD to adapt to the deficiency in energy supply. These changes may be associated with cognitive decline in T2DM patients.