Comparative activity of 2',3'-saturated and unsaturated pyrimidine and purine nucleosides against human immunodeficiency virus type 1 in peripheral blood mononuclear cells.
Comparative activity of 2',3'-saturated and unsaturated pyrimidine and purine nucleosides against human immunodeficiency virus type 1 in peripheral blood mononuclear cells.
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2,3-饱和和不饱和嘧啶和嘌呤核苷在外周血单核细胞中对抗人类免疫缺陷病毒1型的活性比较。
DOI：
10.1016/0006-2952(88)90383-8
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发表时间：
1988
影响因子：
5.8
通讯作者：
Gu,ZP
中科院分区：
文献类型：
--
作者：
Chu,CK;Schinazi,RF;Arnold,BH;Cannon,DL;Doboszewski,B;Bhadti,VB;Gu,ZP
2‘3.尿苷的双脱氧类似物(1，D2U)。胸腺嘧啶核苷(2，D2T)，5-乙基尿苷(3，D2EtU)。和胞苷(4.D2C)是通过3‘-碘核苷脱碘或通过将核糖苷脱氧到相应的2’得到的。2‘，3’-双键还原后的3‘-不饱和核苷[CK Chu，f]。5 Schmazi RF Chu CK。Feorino P和Sommadossi JP。3‘-叠氮多-2’。3‘-二脱氧-5-乙基尿苷(CS-85)--一种新型的选择性抗HTLVS/LAV化合物。第26届抗生素和化疗国际科学会议，洛杉矶新奥尔良，9月1日。28-1986年，奥特1号。
2’3. Dideoxy analogues of uridine (1, D2U). thymidine (2, D2T), 5-ethyluridine(3, D2EtU). and cytidine (4. D2C) were prepared by deiodination of 3’-iodo-nucleosides or by deoxygenation of the ribonucleosides to the corresponding 2’. 3’-unsaturated nucleosides following reduction of the 2’, 3’-double bond [CK Chu, f Authors to whom correspondence should be addressed. 5 Schmazi RF Chu CK. Feorino P and Sommadossi JP. 3’-Azido-2’. 3’-dideoxy-5-ethyluridlne(CS-85)-a new potent selective anti-HTLVS/LAV compound. 26th Interscience Conference on Anlrmrcrobial Agents and Chemotherapy, New Orleans, LA, Sept. 28-Ott 1, 1986.