Pure word deafness and pure anarthria in a patient with frontotemporal dementia
Pure word deafness and pure anarthria in a patient with frontotemporal dementia
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DOI：
10.1111/j.1468-1331.2007.01671.x
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发表时间：
2007-04-01
影响因子：
5.1
通讯作者：
Mori, E.
中科院分区：
文献类型：
--
作者：
Iizuka, O.;Suzuki, K.;Mori, E.
一名66岁的右撇子男子在纯粹的文字失聪后患上了纯粹的无音症。除了语言障碍，他的行为也逐渐改变，最终包括对妻子施暴。脑磁共振成像显示左侧左脑区萎缩，包括中央前回下半部分和颞上回上半部分，与额颞叶痴呆（FTD）一致。它被记录为表达语言的障碍或对单词含义的理解受损。与单纯的无音不同，单纯的文字耳聋不包括在FTD的临床诊断标准中。然而，根据额颞叶皮层病理变化的分布，FTD可出现多种语言症状。本病例提示纯粹的文字耳聋可能是FTD的前驱症状。
A 66-year-old right-handed man developed pure anarthria following pure word deafness. In addition to language disorders, his behavior gradually changed and finally included violence against his wife. Brain magnetic resonance imagings revealed atrophy of the left perisylvian area, which included the inferior half of the precentral gyrus and the upper portion of the superior temporal gyrus, consistent with frontotemporal dementia (FTD). It has been documented as either a disorder of expressive language or as an impaired understanding of word meaning. Unlike with pure anarthria, pure word deafness is not included in the clinical diagnostic current criteria for FTD. However, a large variety of language symptoms can appear in FTD according to the distribution of pathological changes in the frontotemporal cortices. This case suggests that pure word deafness could be a prodomal symptom of FTD.