Effect of volatile anesthetics on synaptic transmission in the rat hippocampus.
Effect of volatile anesthetics on synaptic transmission in the rat hippocampus.
复制标题
挥发性麻醉剂对大鼠海马突触传递的影响。
DOI：
10.1097/00000542-198910000-00019
复制
发表时间：
1989
期刊：
影响因子：
8.8
通讯作者：
Lothman,EW
中科院分区：
文献类型：
--
作者：
Pearce,RA;Stringer,JL;Lothman,EW
氟烷，异氟烷，和安氟醚的突触作用在大鼠海马在体内进行了检查，并与氯胺酮和乌拉坦的影响进行了比较。通过观察刺激对侧CA3区引起的CA1皮层诱发反应和长时程增强，研究了药物对兴奋性氨基酸介导的神经传递的作用。长时程增强是在短暂的刺激序列之后突触功效的持久增加。它已被证明是通过激活兴奋性氨基酸受体的NMDA亚类而建立的，并被认为参与记忆处理。挥发性麻醉药对诱发兴奋性反应或长时程增强没有影响。通过在一定范围的脉冲间隔配对刺激，研究了麻醉剂对海马抑制过程的作用。第一个刺激激活了抑制过程，导致对第二个刺激的反应小于初始反应，这种现象称为成对脉冲抑制。与乌拉坦或氯胺酮相比，挥发性麻醉药的成对脉搏抑制时间显著延长。这些结果表明，挥发性麻醉剂在海马CA1突触的作用机制不涉及氨基酸介导的兴奋，但确实涉及抑制的增强。
The synaptic effects of halothane, isoflurane, and enflurane were examined in the rat hippocampus in vivo and compared with the effects of ketamine and urethane. Actions of the agents on excitatory amino acid-mediated neurotransmission were studied by observing evoked responses and long-term potentiation in the stratum pyramidale of CA1 with stimulation of the contralateral CA3 region. Long-term potentiation is a long-lasting increase in synaptic efficacy, which follows a brief stimulus train. It has been shown to be established through activation of the NMDA subclass of excitatory amino acid receptors and is thought to be involved in memory processing. Volatile anesthetics had no effect on evoked excitatory responses or on long-term potentiation. Actions of the anesthetics on inhibitory processes in the hippocampus were studied by pairing stimuli at a range of interpulse intervals. The first stimulus activated inhibitory processes that caused the response to the second stimulus to be smaller than the initial response, a phenomenon termed paired pulse depression. Paired pulse depression was significantly prolonged by the volatile anesthetics compared with that under urethane or ketamine. These results indicate that the mechanism of action of the volatile anesthetics at the hippocampal CA1 synapse does not involve amino acid-mediated excitation but does involve enhancement of inhibition.