Matrix Metalloproteinase-14 Is a Negative Prognostic Marker for Patients with Gastric Cancer
Matrix Metalloproteinase-14 Is a Negative Prognostic Marker for Patients with Gastric Cancer
复制标题
基质金属蛋白酶-14 是胃癌患者的阴性预后标志物
DOI：
10.1007/s10620-012-2513-9
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发表时间：
2013-05-01
影响因子：
3.1
通讯作者：
Ji, Gang
中科院分区：
文献类型：
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作者：
He, Liang;Chu, Dake;Ji, Gang
背景基质金属蛋白酶-14（MMP-14）在实体瘤的侵袭和转移中起重要作用，本研究旨在探讨MMP-14与胃癌患者总生存率的关系。MMP-14的表达进行了研究，通过免疫组化检测和染色评价结果进行了统计学分析，与患者的总survivals.ResultsMMP-14的表达证明是增加在胃癌与正常组织相比。MMP-14的表达与肿瘤的浸润、转移及TNM分期有关，而与患者的年龄、性别、分化程度及Lauren分期无关。MMP-14阳性表达的胃癌患者的总生存率较MMP-14阴性表达的胃癌患者的总生存率低。MMP-14在胃癌组织中的表达是影响胃癌患者预后的独立因素。
BackgroundMatrix metalloproteinase-14 (MMP-14) has been considered to play an important role in invasion and metastasis of human solid tumor.AimThe present study aimed to investigate the association of MMP-14 with overall survival in human gastric cancer.MethodsGastric cancer and adjacent normal specimens were collected from 205 patients who had not received neoadjuvant chemotherapy. MMP-14 expression was investigated by immunohistochemistry assay and staining evaluation results were analyzed statistically in relation to overall survival of patients.ResultsMMP-14 expression proved to be increased in gastric cancer compared with that in normal tissues. It was also proved that MMP-14 expression was associated with tumor invasion, metastasis, and TNM stage while no correlations were detected between MMP-14 expression and age, sex, differentiation status, or Lauren’s classification. Moreover, patients with gastric cancer of MMP-14-positive expression tend to have worse overall survival compared with those with MMP-14 negative expression.ConclusionsThe present study confirmed the over-expression of MMP-14 in human gastric cancer and its association with tumor progression. It also provided the first evidence that MMP-14 expression in gastric cancer was an independent negative prognostic factor of patients.