Hypoxia-Mediated Biological Control
Hypoxia-Mediated Biological Control
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DOI：
10.1002/jcb.22956
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发表时间：
2011-03-01
影响因子：
4
通讯作者：
Lounsbury, Karen M.
中科院分区：
文献类型：
--
作者：
Cassavaugh, Jessica;Lounsbury, Karen M.
当氧气需求大于氧气供应时，细胞需要迅速调整其新陈代谢，以使组织存活。生物体的氧感测影响许多过程，包括生长、发育、代谢、pH稳态和血管生成。缺氧还导致多种人类疾病，包括血管疾病、炎症和癌症。最近，在理解细胞和组织对缺氧的反应方面取得了重大进展，其目标是提供机制见解和新的治疗靶点。在这篇文章中，我们回顾了缺氧的正常生物学效应以及在特定疾病条件下发生的改变，重点是与慢性缺氧相关的变化背后的细胞信号传导和基因转录机制。心脏缺血和肿瘤血管生成领域研究的比较揭示了控制缺氧反应的微环境的复杂性。很明显，这些领域的研究人员之间的更多互动将促进促进或预防缺氧反应的疗法的发展。J.细胞。112：735-744，2011. (C)2011 Wiley-Liss，Inc.
When oxygen demand is greater than oxygen supply, cells need to rapidly adjust their metabolism in order for the tissue to survive. Oxygen sensing by an organism influences a host of processes including growth, development, metabolism, pH homeostasis, and angiogenesis. Hypoxia also contributes to a wide number of human diseases including vascular disease, inflammatory conditions and cancer. Recently, major advances have been made in understanding the response of cells and tissues to hypoxia with the goal of providing mechanistic insight and novel therapeutic targets. In this article we review both the normal biological effects of hypoxia as well as the alterations that occur in specific disease conditions with an emphasis on the cell signaling and gene transcription mechanisms that underlie the changes associated with chronic hypoxia. Comparisons of studies in the fields of cardiac ischemia and tumor angiogenesis reveal the complexities within the microenvironment that control responses to hypoxia. It is clear that more interaction between researchers in these fields will improve the development of therapies that either promote or prevent hypoxic responses. J. Cell. Biochem. 112: 735-744, 2011. (C) 2011 Wiley-Liss, Inc.