Ultraviolet solid-state laser (213-nm) photorefractive keratectomy. In vivo study.
Ultraviolet solid-state laser (213-nm) photorefractive keratectomy. In vivo study.
复制标题
紫外固体激光（213 nm）屈光性角膜切除术。
DOI：
10.1016/s0161-6420(93)31390-4
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发表时间：
1993
期刊：
影响因子：
13.7
通讯作者：
M. Savoldelli
中科院分区：
文献类型：
--
作者：
Q. Ren;G. Simón;J. Legeais;J. Parel;W. Culbertson;J. Shen;Y. Takesue;M. Savoldelli
背景：用远紫外光谱区的固态激光源取代氟化氩（193 nm）气体准分子激光器将消除气体激光器的危害，并减小其尺寸，这是光折射角膜切除术所期望的。作者研究了使用五倍频（213 nm）脉冲（10 ns）Nd：YAG激光耦合到计算机控制的光学扫描传输system.Methods：使用250 ± 15 mJ/cm 2辐射曝光量消融人尸体眼和兔眼的5 mm光学区的角膜重塑。213 nm激光脉冲通过计算机控制的光学扫描传输系统传输并成形，在角膜上产生具有准高斯能量分布的0.5 mm光斑。角膜表面变化通过计算机辅助角膜地形图记录。光学显微镜，扫描电子显微镜，透射电子显微镜检查角膜表面质量和细胞components.Results的影响：角膜地形测量显示近视矫正范围从2.3到6.1屈光度。术后裂隙灯及手术显微镜检查结果显示，切削表面光滑，无角膜混浊。组织学结果显示光滑的斜面，无可识别的台阶。表面质量和细胞的影响是类似的，以前描述的准分子激光屈光性角膜切除术。结论：作者表明，紫外线（213 nm）的固态激光耦合到一个光学扫描传输系统是能够重塑平滑过渡的角膜表面。扫描光束传输系统可以提供产生空间分辨的、定制的非球面矫正的优点，以优化屈光性角膜切除术后的视觉质量。
Background:Replacing the gas argon fluoride (193 nm) excimer laser with a solid-state laser source in the far-ultraviolet spectrum region would eliminate the hazards of a gas laser and would reduce its size, which is desirable for photorefractive keratectomy. The authors investigated corneal reshaping using a frequency-quintupled (213 nm) pulsed (10 ns) neodymium:YAG laser coupled to a computer-controlled optical scanning delivery system.Methods:A 250 ± 15-mJ/cm2radiant exposure was used to ablate a 5-mm optical zone in human cadaver eyes and rabbit eyes. The 213-nm laser pulses were delivered through and shaped by a computer-controlled optical scanning delivery system, producing a 0.5-mm spot with a quasi-Gaussian energy distribution on the cornea. Corneal surface changes were documented by computer-assisted corneal topography. Light microscopy, scanning electron microscopy, and transmission electron microscopy were performed to examine the effects on corneal surface quality and cellular components.Results:Corneal topographic measurements showed myopic corrections ranging from 2.3 to 6.1 diopters. Results of postoperative examination with the slit lamp and operating microscope demonstrated a smoothly ablated surface without corneal haze. Histologic results showed a smoothly sloping surface without recognizable steps. The surface quality and cellular effects were similar to that of previously described excimer photorefractive keratectomy.Conclusion:The authors demonstrated that an ultraviolet (213-nm) solid-state laser coupled to an optical scanning delivery system is capable of reshaping the corneal surface with smooth transition. The scanning beam delivery system may offer the advantage of producing spatially resolved, customized, aspheric corrections to optimize the quality of vision after photorefractive keratectomy.