Prevalence of serum autoantibodies and paraproteins in patients with glaucoma
Prevalence of serum autoantibodies and paraproteins in patients with glaucoma
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DOI：
10.1038/sj.eye.6702613
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发表时间：
2008-03-01
期刊：
影响因子：
3.9
通讯作者：
Imrie, F.
中科院分区：
文献类型：
--
作者：
Hammam, T.;Montgomery, D.;Imrie, F.
目的探讨正常眼压性青光眼（NTG）与自身免疫的关系，方法对31例正常眼压性青光眼（NTG），32例原发性开角型青光眼（POAG）和32例年龄、性别相匹配的正常对照者的血清进行检测。结果NTG组ANA和ENA阳性的相对危险度分别为对照组的2.5倍和4.4倍，而NTG组ANA和ENA阳性的相对危险度分别为对照组的2.5倍和4.4倍。NTG和对照组的伊加水平之间存在统计学显著差异（P = 0.024），但两组之间关于IgM或IgG水平的差异无统计学显著性。POAG组ANA和ENA阳性的相对危险度分别是对照组的0.77倍和2.9倍。POAG组检出副蛋白的相对危险度是对照组的0.97倍。POAG患者血清伊加水平与对照组比较差异有统计学意义（P = 0.011），但两组血清IgM、IgG水平差异无统计学意义（P> 0.05）。结论NTG的发病可能与体液免疫有关。
Purpose To investigate the possible link between normal tension glaucoma (NTG) and autoimmunity.Methods We studied the serum of 95 patients: 31 with NTG, 32 with primary open-angle glaucoma (POAG), and 32 age- and sex-matched controls. Blood was drawn from each patient and serum was examined for the presence of antinuclear antigens (ANA), autoantibodies to extractable nuclear antigens (ENA), anti-double-strand DNA, serum protein electrophoresis, and immunoglobulin (IgG, IgA, and IgM) levels.Results In the NTG group, the relative risks for ANA and ENA positivity were 2.5 and 4.4 times, respectively, that of the control group. There was a statistically significant difference between IgA levels in the NTG and control group (P = 0.024), but there was no statistically significant difference between both groups regarding IgM or IgG levels. In the POAG group, the relative risks for ANA and ENA positivity were 0.77 and 2.9 times, respectively, that of the control group. The relative risk for detection of paraprotein in the POAG group was 0.97 times that of the control group. Also, there was a statistically significant difference between IgA levels in the POAG and control group (P = 0.011), but there was no statistically significant difference between both groups regarding IgM or IgG.Conclusion These results support the hypothesis that humoral immune mechanisms may have a role in the pathogenesis of NTG.