INTRASPECIFIC PHYLOGENETICS - SUPPORT FOR DENTAL TRANSMISSION OF HUMAN-IMMUNODEFICIENCY-VIRUS
INTRASPECIFIC PHYLOGENETICS - SUPPORT FOR DENTAL TRANSMISSION OF HUMAN-IMMUNODEFICIENCY-VIRUS
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DOI：
10.1128/jvi.69.4.2351-2356.1995
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发表时间：
1995-04-01
影响因子：
5.4
通讯作者：
CRANDALL, KA
中科院分区：
文献类型：
--
作者：
CRANDALL, KA
一种新的方法来估计种内基因系谱被用来建立个人之间的联系与佛罗里达牙科人类免疫缺陷病毒传播的情况。根据代表佛罗里达牙医的env基因V3区的103个核苷酸序列、他的8名血清阳性患者和许多当地对照，估计了系统发生关系。分支图估计程序支持个人之间的联系，在先前描述的牙齿分支，而本地控制和其他患者形成独立的网络或在主网络中的离群值，表明更遥远的进化关系。嵌套的统计分析也表明显着的凝聚力的牙科分支组。
A new method to estimate within-species gene genealogies was used to establish linkages among individuals associated with the Florida dental human immunodeficiency virus transmission case. Phylogenetic relationships were estimated from 103 nucleotide sequences from the V3 region of the env gene representing the Florida dentist, eight of his seropositive patients, and many local controls. The cladogram estimation procedure supports linkages among individuals within the previously described dental clade, whereas local controls and other patients form independent networks or are outliers in the main network, indicating more distant evolutionary relationships. A nested statistical analysis also indicates significant cohesion of the dental clade group.