Exosomes mediate the cell-to-cell transmission of IFN-α-induced antiviral activity
Exosomes mediate the cell-to-cell transmission of IFN-α-induced antiviral activity
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外泌体介导 IFN-α 诱导的抗病毒活性的细胞间传递
DOI：
10.1038/ni.2647
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发表时间：
2013-08-01
影响因子：
30.5
通讯作者：
Yuan, Zhenghong
中科院分区：
文献类型：
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作者：
Li, Jianhua;Liu, Kuancheng;Yuan, Zhenghong
病毒耐药性的细胞间传播是放大干扰素诱导的抗病毒反应的潜在机制。在这项研究中，我们报道了干扰素-α(干扰素-α)诱导对乙肝病毒(乙肝病毒)的耐药性从不允许的肝非实质细胞(LNPC)通过外切体转移到允许的肝细胞。干扰素-α处理的LNPC的外切体富含具有抗病毒活性的分子。此外，来自LNPC的外切体被肝细胞内化，从而介导抗病毒分子的细胞间转移。最后，我们发现外切体也有助于干扰素-α对小鼠A59肝炎病毒和腺病毒的抗病毒反应。因此，我们提出了一种干扰素-α活性的抗病毒机制，该机制涉及通过外切体诱导和细胞间转移抗病毒分子。
The cell-to-cell transmission of viral resistance is a potential mechanism for amplifying the interferon-induced antiviral response. In this study, we report that interferon-alpha (IFN-alpha) induced the transfer of resistance to hepatitis B virus (HBV) from nonpermissive liver nonparenchymal cells (LNPCs) to permissive hepatocytes via exosomes. Exosomes from IFN-alpha-treated LNPCs were rich in molecules with antiviral activity. Moreover, exosomes from LNPCs were internalized by hepatocytes, which mediated the intercellular transfer of antiviral molecules. Finally, we found that exosomes also contributed to the antiviral response of IFN-alpha to mouse hepatitis virus A59 and adenovirus in mice. Thus, we propose an antiviral mechanism of IFN-alpha activity that involves the induction and intercellular transfer of antiviral molecules via exosomes.