Pellynols M-O, cytotoxic polyacetylenic alcohols from a Niphates sp marine sponge
Pellynols M-O, cytotoxic polyacetylenic alcohols from a Niphates sp marine sponge
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Pellynols M-O，来自 Niphates sp 的细胞毒性聚乙炔醇。
DOI：
10.1016/j.tet.2018.05.041
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发表时间：
2018-07-05
期刊：
影响因子：
2.1
通讯作者：
Lin, Hou-Wen
中科院分区：
文献类型：
--
作者：
Wang, Jie;Liu, Li-Yun;Lin, Hou-Wen
从 Niphates sp. 中分离出三种新的聚炔醇，pellynols M-O (1-3)，以及两种已知的聚炔醇，melyne A (4) 和 melyne B (5)。从南中国海采集的海绵。新化合物的结构是基于一维和二维核磁共振分析、ESI-MSn 裂解和化学（臭氧分解）方法的组合确定的。它们的绝对构型是通过修改后的Mosher 方法指定的。所有分离株均对 PC9 和 HepG2 人类癌细胞系表现出有效的细胞毒活性，IC50 值为 2.9-7.6 muM。 (C) 2018 Elsevier Ltd. 保留所有权利。
Three new polyacetylenic alcohols, pellynols M-O (1-3), along with two known ones, melyne A (4) and melyne B (5), were isolated from a Niphates sp. marine sponge collected off the South China Sea. The structures of new compounds were determined based on a combination of 1D and 2D NMR analysis, ESI-MSn fragmentation, and chemical (ozonolysis) method. Their absolute configurations were assigned by modified Mosher's method. All the isolates showed potent cytotoxic activity against PC9 and HepG2 human cancer cell lines with IC50 values of 2.9-7.6 mu M. (C) 2018 Elsevier Ltd. All rights reserved.