Discriminative cues produced by NPY do not generalize to the interoceptive cues produced by food deprivation.
Discriminative cues produced by NPY do not generalize to the interoceptive cues produced by food deprivation.
复制标题
NPY 产生的辨别线索并不能推广到食物剥夺产生的内感受线索。
DOI：
10.1016/0031-9384(95)02074-8
复制
发表时间：
1995
影响因子：
2.9
通讯作者：
Davidson,TL
中科院分区：
文献类型：
--
作者：
Seeley,RJ;Benoit,SC;Davidson,TL
外源性神经肽Y（NPY）进入第三脑室引起快速和强大的进食反应，在饱食大鼠。目前的实验旨在评估是否由外源性神经肽Y管理产生的内感受性线索推广到另一个食欲治疗：24小时的食物剥夺。在接受NPY或盐水输注到第三脑室后，将大鼠放置在一个室中，总共六次（NPY后三次，盐水后三次）。一半的大鼠在注射NPY后接受短暂的足部电击，而不是在注射生理盐水后，而另一半则接受相反的应急措施。两组的行为不动模式不同，大鼠“冻结”显著更多的治疗（NPY或生理盐水）与休克配对。然后，将大鼠在0或24小时食物剥夺后放入室中，不给予NPY或盐水或任何足部电击，测试大鼠的泛化能力。行为不动性在泛化测试的大鼠，已训练与休克后，盐水是大于已训练与休克后，NPY的大鼠，独立的测试是否发生时，大鼠0或24小时的食物剥夺。这一结果表明，内感受性刺激产生的神经肽Y是没有更多的类似于内部线索产生的24小时食物剥夺比随意喂养的刺激后果。这些和其他最近的研究结果表明，食物剥夺激活的过程或机制不同于那些神经肽Y的食欲作用的基础。
Exogenous administration of neuropeptide Y (NPY) into the third ventricle causes a rapid and robust feeding response in sated rats. The current experiment was designed to assess whether the interoceptive cues produced by exogenous NPY administration generalize to those produced by another orexigenic treatment: 24-h food deprivation. Rats were placed in a chamber after receiving either NPY or saline infused into the third ventricle for a total of six sessions (three after NPY and three after saline). Half of the rats were given a brief foot shock after NPY and not after saline, while the other half received the opposite contingency. The pattern of behavioral immobility for the two groups differed with the rats “freezing” significantly more to the treatment (NPY or saline) paired with shock. Then rats were tested for generalization by placing them in the chamber either after 0- or 24-h food deprivation with no NPY or saline administration or any foot shock. Behavioral immobility during the generalization test of rats that had been trained with shock following saline was greater than that for rats that had been trained with shock following NPY, independent of whether testing occurred when the rats were 0- or 24-h food deprived. This outcome indicates that interoceptive stimuli produced by NPY are no more similar to internal cues produced by 24-h food deprivation than to the stimulus consequences of ad lib feeding. These and other recent findings suggest that food deprivation activates processes or mechanisms different from those that underlie the orexigenic effects of NPY.