Sensitive Periods for Hormonal Programming of the Brain
Sensitive Periods for Hormonal Programming of the Brain
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DOI：
10.1007/7854_2014_286
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发表时间：
2014-01-01
期刊：
影响因子：
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通讯作者：
Paul, Matthew J.
中科院分区：
文献类型：
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作者：
de Vries, Geert J.;Fields, Christopher T.;Paul, Matthew J.
在敏感时期，特定发育阶段发生的来自外部和内部环境的信息被传递到大脑以编程神经发育。激素在此过程中发挥着核心作用。在这篇综述中，我们首先讨论大脑的性别分化，作为激素编程的一个例子。利用性别分化，我们定义了敏感期，回顾了可以解释其受限时间窗口的细胞和分子过程，并讨论了确定时间窗口的精确时间的挑战。然后，我们简要回顾其他激素系统的编程效果，并讨论这些系统的编程如何与性别分化相互作用。
During sensitive periods, information from the external and internal environment that occurs during particular phases of development is relayed to the brain to program neural development. Hormones play a central role in this process. In this review, we first discuss sexual differentiation of the brain as an example of hormonal programming. Using sexual differentiation, we define sensitive periods, review cellular and molecular processes that can explain their restricted temporal window, and discuss challenges in determining the precise timing of the temporal window. We then briefly review programming effects of other hormonal systems and discuss how programming of these systems interact with sexual differentiation.