MACC1: A potential molecule associated with pancreatic cancer metastasis and chemoresistance
MACC1: A potential molecule associated with pancreatic cancer metastasis and chemoresistance
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MACC1：与胰腺癌转移和化疗耐药相关的潜在分子
DOI：
10.3892/ol.2012.784
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发表时间：
2012-10-01
期刊：
影响因子：
2.9
通讯作者：
Wu, Yu-Lian
中科院分区：
文献类型：
--
作者：
Wang, Gang;Kang, Mu-Xing;Wu, Yu-Lian
研究表明，新发现的结肠癌转移相关基因1（MACC 1）参与了癌症的进展和转移。一些研究表明MACC 1具有作为新生物标志物的潜力。本研究旨在探讨MACC 1在胰腺癌患者血清中的表达水平及其功能。通过ELISA分析来自60名癌症患者和49名对照的血清样品的血清MACC 1。结果显示MACC 1的高表达与淋巴结转移、远处转移及TNM分期有关。通过siRNA抑制MACC 1显著抑制胰腺癌细胞增殖和迁移。此外，发现MACC 1的下调通过抑制Ras/ERK信号传导途径使胰腺癌细胞对吉西他滨治疗敏感。我们的研究结果表明，MACC 1可能有助于胰腺癌的诊断，并作为一个潜在的治疗靶点。
It has been suggested that the newly identified metastasis-associated in colon cancer-1 (MACC1) oncogene is involved in the progression and metastasis of cancer. Several studies have indicated that MACC1 has potential as a novel biomarker. In this study, we aimed to investigate the functions and serum expression levels of MACC1 in pancreatic cancer patients. Blood serum samples from 60 cancer patients and 49 controls were analyzed for serum MACC1 by ELISA. The results revealed that high expression levels of MACC1 were correlated with lymph node metastasis, distant metastasis and a later TNM stage. Inhibition of MACC1 by siRNAs significantly suppressed pancreatic cancer cell proliferation and migration. Furthermore, it was found that the downregulation of MACC1 sensitized pancreatic cancer cells to gemcitabine treatment through the inhibition of the Ras/ERK signaling pathway. Our findings suggest that MACC1 may aid in the diagnosis of pancreatic cancer and serve as a potential therapeutic target.