Interactions of mitochondrial ATP synthesis and the creatine kinase equilibrium in skeletal muscle.
Interactions of mitochondrial ATP synthesis and the creatine kinase equilibrium in skeletal muscle.
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骨骼肌中线粒体 ATP 合成与肌酸激酶平衡的相互作用。
DOI：
10.1006/jtbi.1994.1184
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发表时间：
1994
影响因子：
2
通讯作者：
Graham J. Kemp
中科院分区：
文献类型：
--
作者：
Graham J. Kemp
在骨骼肌中，肌酸激酶对磷酸肌酸、肌酸、ATP和ADP的浓度施加了约束，这使我们对线粒体ATP合成调节的理解复杂化，因为氧化速率(Q)和代谢物浓度之间的相关性不能证明因果关系。基于(i) Q与胞质[ADP]之间的双曲关系和（ii） Q与ATP水解自由能（例如）之间的线性相关性，已经发展出两种线粒体体内控制理论。本文研究了这些理论之间的一些关系，以显示(i)它们在多大程度上可以被视为相同代谢机制的不同表达，（ii）如何根据反馈控制的一般原则来理解它们，以及（iii）它们如何解释线粒体功能与静息代谢物浓度之间的关系。
In skeletal muscle, creatine kinase imposes constraints on the concentrations of phosphocreatine, creatine, ATP and ADP, which complicate our understanding of the regulation of mitochondrial ATP synthesis, because correlations between oxidation rate (Q) and metabolite concentrations cannot prove causal relations. Two kinds of theory of mitochondrial control in vivo have evolved, based on (i) the hyperbolic relationship between Q and cytosolic [ADP] and (ii) linear correlations between Q and, for example, free energy of ATP hydrolysis. This paper examines some relationships between these theories in order to show (i) to what extent they may be regarded as different expressions of the same metabolic mechanisms, (ii) how they can be understood in terms of general principles of feedback control, and (iii) how they explain relationships between mitochondrial function and resting metabolite concentrations.