Effects of combined pre- and post-natal enrichment on anxiety-like, social, and cognitive behaviours in juvenile and adult rat offspring
Effects of combined pre- and post-natal enrichment on anxiety-like, social, and cognitive behaviours in juvenile and adult rat offspring
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DOI：
10.1016/j.bbr.2018.06.033
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发表时间：
2018-11-01
影响因子：
2.7
通讯作者：
Bielajew, Catherine
中科院分区：
文献类型：
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作者：
Sparling, Jessica E.;Baker, Stephanie L.;Bielajew, Catherine
产前和产后时期的特点是无与伦比的增长和对环境变化敏感。正确刺激的早期环境对于发展自然行为和保持情感健康至关重要。5窝大鼠子代在整个妊娠期至幼龄期间共同圈养在提供身体和社会丰富的圈养环境中。在标准条件下单独圈养5窝对照窝。一半的后代在高架十字迷宫和社会互动测试作为青少年（5周龄）与另一半在莫里斯水迷宫测试。作为成年人（11周龄），测试组被颠倒。每周监测体重。富集后代体重更轻。在高架十字迷宫中，对照组幼仔在开放臂中花费的时间百分比更高，表现出更大的运动活性，更少的梳理和更多的饲养（仅限雄性）。在社会互动测试中，丰富的少年后代被发现嗅他们的同种更多，显示更多的自我梳理行为，以及显示较少的运动活动和身体接触。在Morris水迷宫探针测试中，丰富的大鼠表现出改善的记忆平台的位置和更有效的搜索策略，增加平台交叉，中间交叉，以及更多的时间花在平台象限和更少的趋触行为。成年雌性大鼠后代也表现出对平台位置的上级记忆，并更频繁地穿过迷宫中间。这些结果表明，结合产前和产后的环境丰富的影响，在后代大鼠的生理和行为，其中一些影响是持久的。
The pre- and post-natal periods are characterized by unrivalled growth and are sensitive to environmental changes. A correctly stimulating early environment is essential for developing natural behaviors and maintaining affective wellness. Five litters of rat progeny were co-housed through gestation until juvenile age in housing providing physical and social enrichment. Five control litters were housed separately in standard conditions. Half of the offspring were tested in the elevated plus-maze and the social interaction test as juveniles (five weeks old) with the other half tested in the Morris water maze. As adults (11 weeks old), the testing groups were reversed. Weight was monitored weekly. Enriched offspring had leaner body weights. In the elevated plus-maze, control juvenile progeny spent a higher percentage of time in the open arms, showed greater locomotor activity, less grooming, and more rearing (males only). In the social interaction test, enriched juvenile offspring were found to sniff their conspecific more, display more self-grooming behaviour as well as show less locomotor activity and body contact. In the Morris water maze probe test, enriched rats demonstrated improved memory for the platform position and more effective search strategies with increased platform crossings, middle crossing as well as more time spent in the platform quadrant and less thigmotaxis behaviour. Adult female rat offspring also demonstrated superior memory for the platform position and crossed the maze middle more often. These results suggest that combined pre- and post-natal environmental enrichment influences physiology and behaviour in offspring rats with some of those influences being long-lasting.