Lack of adenosine A1 and dopamine D2 receptor-mediated modulation of the cardiovascular effects of the adenosine A2A receptor agonist CGS 21680.
Lack of adenosine A1 and dopamine D2 receptor-mediated modulation of the cardiovascular effects of the adenosine A2A receptor agonist CGS 21680.
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缺乏腺苷 A1 和多巴胺 D2 受体介导的腺苷 A2A 受体激动剂 CGS 21680 的心血管效应调节。
DOI：
10.1016/j.ejphar.2003.11.010
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发表时间：
2004
影响因子：
5
通讯作者：
Ferre,Sergi
中科院分区：
文献类型：
--
作者：
Schindler,CharlesW;Karcz-Kubicha,Marzena;Thorndike,EricB;Muller,ChristaE;Tella,SrihariR;Goldberg,StevenR;Ferre,Sergi
Some behavioral and biochemical effects of the systemically administered adenosine A2Areceptor agonist 2-p-(2-carboxyethyl)phenethylamino-5′-N-ethylcarboxamidoadenosine (CGS 21680) in rats are potentiated by adenosine A1receptor agonists and counteracted by dopamine D2 receptor agonists. In the present study we compared potentiating and antagonistic interactions between CGS 21680 and adenosine A1and dopamine D2 receptor agonists on motor activity and on cardiovascular responses (arterial blood pressure and heart rate). The motor-depressant effects produced by CGS 21680 (0.5 mg/kg, i.p.) were potentiated by the adenosine A1receptor agonist N6-cyclopentyladenosine (CPA, 0.3 mg/kg, i.p.) and counteracted by the dopamine D2 receptor agonist quinpirole (0.5 mg/kg, i.p.). In contrast, neither CPA nor quinpirole significantly modified the decrease in arterial pressure or the increase in heart rate induced by CGS 21680. However, the adenosine A2Areceptor antagonist 3-(3-hydroxypropyl)-8-(m-methoxystyryl)-7-methyl-1-propargylxanthine phosphate disodium salt (MSX-3, 3 mg/kg, i.p.) counteracted both the motor-depressant and cardiovascular effects of CGS 21680. Therefore, the effects of the systemically administered adenosine A2Areceptor agonist CGS 21680 on cardiovascular function, in contrast to its effects on motor behavior, appear to be independent of the effects of adenosine A1and dopamine D2 receptor activity.
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DOI：
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期刊：
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期刊：
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