Biomarkers of blast-induced neurotrauma: profiling molecular and cellular mechanisms of blast brain injury.
Biomarkers of blast-induced neurotrauma: profiling molecular and cellular mechanisms of blast brain injury.
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爆炸引起的神经创伤的生物标志物：分析爆炸脑损伤的分子和细胞机制。
DOI：
10.1089/neu.2008.0609
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发表时间：
2009
影响因子：
4.2
通讯作者：
Wang,KevinKW
中科院分区：
文献类型：
--
作者：
Svetlov,StanislavI;Larner,StephenF;Kirk,DanielR;Atkinson,Joseph;Hayes,RonaldL;Wang,KevinKW
21世纪世纪战争的性质导致了对整个身体和头部的原发性爆炸或过压损伤的显著增加，其表现为神经-躯体损伤的复合体，包括创伤性脑损伤（TBI）。因此，在原发性冲击波暴露的可重复实验模型中确定相关的致病途径对于开发用于诊断冲击性脑损伤的生物标志物至关重要。比较分析的机制和推定的生物标志物的冲击性脑损伤是复杂的实验研究的不足。在这篇文章中，我们提出了目前的TBI生物标志物的概述，以及概述实验策略，调查爆炸性神经创伤的分子特征，并开发一个新的生物标志物发现的通路网络图。这些生物标志物将有效地分类和管理战斗和平民伤亡。
The nature of warfare in the 21st century has led to a significant increase in primary blast or over-pressurization injuries to the whole body and head, which manifest as a complex of neuro-somatic damage, including traumatic brain injury (TBI). Identifying relevant pathogenic pathways in reproducible experimental models of primary blast wave exposure is therefore vital to the development of biomarkers for diagnostics of blast brain injury. Comparative analysis of mechanisms and putative biomarkers of blast brain injury is complicated by a deficiency of experimental studies. In this article, we present an overview of current TBI biomarkers, as well as outline experimental strategies to investigate molecular signatures of blast neurotrauma and to develop a pathway network map for novel biomarker discovery. These biomarkers will be effective for triaging and managing both combat and civilian causalities.