Two submucosal nerve plexus in human intestines
Two submucosal nerve plexus in human intestines
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DOI：
10.1007/s00418-009-0657-2
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发表时间：
2010-02-01
影响因子：
2.3
通讯作者：
Neuhuber, Winfried
中科院分区：
文献类型：
--
作者：
Brehmer, Axel;Rupprecht, Holger;Neuhuber, Winfried
我们研究了来自12个人（每6个来自小肠和大肠）的肠段的人类粘膜下神经网络的结构。制备12个未分开的粘膜下全标本，并对外周蛋白（神经元素）和α-平滑肌肌动蛋白（附着肌束的残余物）进行化学染色。我们发现了两个神经节网络。粘膜下外丛一般为单层，位于粘膜下全丛的最外表面之下。其神经纤维束常呈锐角或钝角连接，网状结构较宽，多呈多角形。粘膜下内丛通常为多层（多为两层或三层），至少占据整个粘膜厚度的内半部分，有时向腔外延伸超过粘膜下大血管。它的网孔是不规则的。内神经丛和外神经丛的神经节形状不同，内神经丛多呈葡萄状，外神经丛多嵌在神经纤维的轮廓内。两个神经丛通过盘绕的相互连接的股，或有或没有闰神经节强烈连接。对于两个不同的粘膜下神经丛的使用，Meissner（内）和Schabadasch（外）的名称在历史上是合理的。
We examined the architecture of human submucosal nerve networks of gut segments derived from 12 individuals (each six from small and large intestines). Twelve undivided submucosal wholemounts were prepared and immunohistochemically stained for peripherin (nerve elements) and for alpha-smooth muscle actin (remnants of attached muscle bundles). We found two ganglionic nerve networks. The plexus submucosus externus was generally monolayered and located under the outermost surface of the submucosal wholemounts. Its nerve fibre strands frequently joined each other in acute or obtuse angles, the meshes of the network were relatively wide and frequently polyangular shaped. The plexus submucosus internus was generally multi-(mostly two- or three-)layered and occupied at least the inner half of the thickness of the wholemount, sometimes extending abluminally beyond the great submucosal vessels. Its meshes were irregular. The shapes of ganglia of the two plexus were generally different, those of the internal plexus were frequently grape-like whereas the neurons of external ganglia were mostly embedded in the contoures of the joining nerve fibres. Both plexus were intensely connected via coiled interconnecting strands, either with or without intercalated ganglia. For use of eponyms for two different submucosal plexus, the names of Meissner (inner) and Schabadasch (outer) are historically justified.