The effects of various secretagogues on the mucin content of pure submandibular salivas.
The effects of various secretagogues on the mucin content of pure submandibular salivas.
复制标题
各种促分泌剂对纯下颌下唾液粘蛋白含量的影响。
DOI：
10.1177/00220345870660050301
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发表时间：
1987
影响因子：
7.6
通讯作者：
Yim,MS
中科院分区：
文献类型：
--
作者：
Denny,PC;Denny,PA;Yim,MS
比较了毛果芸香碱（PILO）、肾上腺素（EPI）和异丙肾上腺素（IPR）诱导的小鼠下颌下腺唾液中特定粘蛋白和总蛋白的浓度。在所采用的剂量下，IPR刺激的样品平均含有最高浓度的蛋白质和粘蛋白。EPI样本含有中等浓度，PILO浓度最低。PILO唾液样品中的平均粘蛋白与蛋白质比率介于IPR和EPI样品之间。非刺激的唾液样本显示了更广泛的粘蛋白总蛋白比刺激的唾液集。在PILO唾液样品中，唾液的粘蛋白含量与刺激前分泌腺中的粘蛋白含量之间存在非常强的正相关性。EPI和IPR样品的粘蛋白含量也与腺体中的粘蛋白含量呈强正相关。EPI唾液样本中的粘蛋白和蛋白质在至少一个集合中显着相关，而在IPR样本中，有一个弱得多的关系。除EPI唾液的第三次连续收集外，所有其他EPI、IPR和PILO收集组中的九个仅显示流速与唾液粘蛋白或蛋白质含量之间的弱负相关或无相关性。这与当所有数据组合时在唾液蛋白或粘蛋白含量与流速之间注意到的强烈负相关性形成鲜明对比。这些观察结果表明，刺激物的性质是一个非常重要的决定因素的整体流量，唾液蛋白，粘蛋白浓度。然而，在个人层面上，控制每一个因素的因素往往没有得到有力的协调。
The concentrations of a specific mucin and total protein were compared in pure submandibular saliva samples elicited by pilocarpine (PILO), epinephrine (EPI), and isoproterenol (IPR) in mice. At the dosages employed, IPR-stimulated samples contained, on the average, the highest concentrations of protein and mucin. EPI samples contained intermediate levels, and PILO the lowest concentrations. The average mucin-to-protein ratio in the PILO saliva samples was intermediate between the IPR and EPI samples. Non-stimulated saliva samples showed a broader range of mucin to total protein than did the stimulated saliva sets. Within the PILO saliva samples, there was a very strong positive correlation between the mucin content of saliva and the mucin content in the pre-secretory gland prior to stimulation. The mucin content of EPI and IPR samples also showed strong positive relationships with the content of mucin in the gland. The mucin and protein in EPI saliva samples were significantly correlated in at least one of the collections, whereas in the IPR samples, there was a much weaker relationship. With the exception of the third sequential collection of EPI saliva, all nine of the other EPI, IPR, and PILO collection sets showed only a weakly negative or no correlation between flow rate and saliva mucin or protein content. This is in sharp contrast with the strongly negative correlalion which was noted between saliva protein or mucin contents and flow rate when all of the data were combined. These observations suggest that the nature of the stimulant is a very important determinant of overall flow rates, saliva protein, and mucin concentrations. However, at the individual level, factors which control each are often not strongly coordinated.