Responses to hypercarbia induced by acetazolamide in panic disorder patients.
Responses to hypercarbia induced by acetazolamide in panic disorder patients.
复制标题
恐慌症患者对乙酰唑胺引起的高碳酸血症的反应。
DOI：
10.1176/ajp.146.8.996
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发表时间：
1989
期刊：
影响因子：
--
通讯作者：
Tant,S
中科院分区：
文献类型：
--
作者：
Mathew,RJ;Wilson,WH;Tant,S
据报道，CO2吸入会诱发惊恐障碍患者的惊恐发作。在双盲条件下，在惊恐障碍患者静脉注射1 g乙酰唑胺（13例患者）和生理盐水（10例患者）之前和之后监测状态焦虑、焦虑的躯体症状、生理变化和脑血流量（CBF）。尽管有明显的高碳酸血症，如前一组CBF增加所证明的，但只有一名受试者报告恐慌，甚至这种发作也不符合DSM-III-R标准。药物组和安慰剂组之间只有一个显著性差异;乙酰唑胺组的头晕明显更多。
CO2 inhalation has been reported to induce panic attacks in panic disorder patients. State anxiety, somatic symptoms of anxiety, physiological changes, and cerebral blood flow (CBF) were monitored in panic disorder patients before and after intravenous injections of 1 g of acetazolamide (13 patients) and saline (10 patients), given under double-blind conditions. In spite of significant hypercarbia, as evidenced by increased CBF in the former group, only one subject reported panic and even that attack did not meet DSM-III-R criteria. There was only one significant difference between the drug and placebo groups; the acetazolamide group experienced significantly more dizziness.