Viral inhibitors of NKG2D ligands: Friends or foes of immune surveillance?
Viral inhibitors of NKG2D ligands: Friends or foes of immune surveillance?
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DOI：
10.1002/eji.200838823
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发表时间：
2008-11-01
影响因子：
5.4
通讯作者：
Krmpotic, Astrid
中科院分区：
文献类型：
--
作者：
Jonjic, Stipan;Polic, Bojan;Krmpotic, Astrid
NKG2D 是 NK 细胞上的有效激活受体，也是 CD8(+) T 细胞上的共刺激受体。通过其识别由应激或感染诱导的一组配体的能力，它在控制病毒感染中发挥着重要作用。这些病毒已经进化出强大的机制来对抗 NKG2D 依赖性免疫反应。这些病毒抑制剂的功能在感染后的早期得到了很好的表征，但在慢性病毒感染期间则不太清楚。
NKG2D is a potent activating receptor on NK cells and a co-stimulatory receptor on CD8(+) T cells. Through its ability to recognize a panel of ligands inducible by stress or infection, it plays an important role in the control of viral infections. The viruses have evolved robust mechanisms to counteract NKG2D-dependent immune response. The functions of these viral inhibitors are well characterized during the early days post-infection but less so during the chronic viral infection.