CACNA1C: Association With Psychiatric Disorders, Behavior, and Neurogenesis
CACNA1C: Association With Psychiatric Disorders, Behavior, and Neurogenesis
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DOI：
10.1093/schbul/sby096
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发表时间：
2018-09-01
影响因子：
6.6
通讯作者：
Hall, Jeremy
中科院分区：
文献类型：
--
作者：
Moon, Anna L.;Haan, Niels;Hall, Jeremy
大规模全基因组关联研究一致表明，CACNA1C（一种编码钙电压门控通道亚基 alpha1C 的基因）的遗传变异会增加精神疾病的风险。 CACNA1C 编码电压门控钙通道的 Ca(v)1.2 亚基，其本身在功能上与多种神经精神综合征有关。研究集中于揭示可能导致这种风险增加的潜在生物机制。这篇综述概述了动物模型中 Cacna1c 变异的最新发现，特别关注与神经发育障碍相关的行为表型，例如认知、焦虑和抑郁表型以及恐惧条件反射。还评估了 Cacna1c 基因剂量减少对成年海马神经发生的影响，包括来自新型 Cacna1c(+/-) 大鼠模型的新数据。
Large-scale genome-wide association studies have consistently shown that genetic variation in CACNA1C, a gene that encodes calcium voltage-gated channel subunit alpha1C, increases risk for psychiatric disorders. CACNA1C encodes the Ca(v)1.2 subunit of voltage-gated calcium channels, which themselves have been functionally implicated in a broad spectrum of neuropsychiatric syndromes. Research has concentrated on uncovering the underlying biological mechanisms that could be responsible for this increased risk. This review presents an overview of recent findings regarding Cacna1c variation in animal models, particularly focusing on behavioral phenotypes associated with neurodevelopmental disorders such as cognition, anxiety and depressive phenotypes, and fear conditioning. The impact of reduced gene dosage of Cacna1c on adult hippocampal neurogenesis is also assessed, including new data from a novel Cacna1c(+/-) rat model.