Interaction between chronic amphetamine and neuroleptic treatments on oral behavior in rats.
Interaction between chronic amphetamine and neuroleptic treatments on oral behavior in rats.
复制标题
慢性安非他明和精神安定药物治疗对大鼠口腔行为的相互作用。
DOI：
10.1007/bf00179937
复制
发表时间：
1987
影响因子：
3.4
通讯作者：
Ellison,GD
中科院分区：
文献类型：
--
作者：
Levy,AD;Ellison,GD
The interaction of concurrently administered amphetamine (AMPH) and haloperidol (HAL) on behavior was examined. Rats were divided into four groups: drug naive controls; HAL-treated for 6 months; AMPH-treated for 1 month; and rats administered both continuous HAL for 6 months and concurrent AMPH treatment during the 2nd month of HAL administration. AMPH alone increased locomotor activity, and this effect was blocked by concurrent haloperidol administration; however, the AMPH-induced reduction of body weight was unaltered by concurrent haloperidol treatment. Oral behavior, monitored both by a human observer and a computerized system, was not significantly altered by HAL alone, or by AMPH alone, but increases in tremorous oral behavior appeared in the concurrent administration group 4 months after AMPH treatment was discontinued. These results could have implications for tardive dyskinesia.
