Elevated hematocrit in nonalcoholic fatty liver disease: A potential cause for the increased risk of cardiovascular disease?
Elevated hematocrit in nonalcoholic fatty liver disease: A potential cause for the increased risk of cardiovascular disease?
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DOI：
10.3233/ch-2011-1509
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发表时间：
2012-01-01
影响因子：
2.1
通讯作者：
Yin, Dazhong
中科院分区：
文献类型：
--
作者：
Li, Guolin;Hu, Hui;Yin, Dazhong
背景与目的：红细胞压积是一项重要的血液流变学指标。红细胞压积和非酒精性脂肪性肝病（NAFLD）都与心血管疾病密切相关。方法：对1,821名中国汉族成人的红细胞压积水平进行分析，并通过问卷调查和体格检查了解和怀疑红细胞压积与NAFLD的关系。多因素校正比值比表明，与红细胞压积最低四分位数相比，最高四分位数受试者发生NAFLD的风险在男性和女性中分别增加185%和386%。进一步的受试者操作特征分析表明，红细胞压积检测NAFLD的最佳临界值男性为42.75，女性为37.55。不健康的生活方式对NAFLD和红细胞压积有相似的影响。结论：NAFLD的患病率与红细胞压积水平呈正相关。虽然NAFLD与红细胞压积之间的因果关系仍需进一步研究，但NAFLD患者红细胞压积升高可能对NAFLD与心血管疾病的联系具有重要意义。
Background and aim: Hematocrit is an important hemorheological parameter. Both hematocrit and nonalcoholic fatty liver disease (NAFLD) are strongly correlated with cardiovascular disease. However, there is no study to explore the direct relationship of hematocrit with NAFLD.Methods: Hematocrit levels were analyzed from 1,821 Chinese Han adults, and questionnaire and physical examination were administered to know and suspect the relationship with NAFLD.Results: NAFLD morbidity was positively correlated with hematocrit levels in both male and female. Multivariate-adjusted odds ratio illustrated that, compared with the lowest quartile of hematocrit, the highest quartile subjects had a 185% and 386% increased risk for developing NAFLD in male and female, respectively. Further receiver operating characteristic analysis showed that the optimal cutoff value of hematocrit for detecting NAFLD was 42.75 in male and 37.55 in female. Unhealthy lifestyles had similar effects on NAFLD and hematocrit.Conclusions: The prevalence of NAFLD is positively associated with hematocrit levels. Though the cause-effect relationship between NAFLD and hematocrit still needs further investigation to clarify, the elevated hematocrit in NAFLD patients may be of significance to link NAFLD and cardiovascular disease.