Association of noninvasively measured renal protein biomarkers with histologic features of lupus nephritis.
Association of noninvasively measured renal protein biomarkers with histologic features of lupus nephritis.
复制标题
DOI：
10.1002/art.34426
复制
发表时间：
2012-08
影响因子：
--
通讯作者：
Devarajan, Prasad
中科院分区：
文献类型：
--
作者：
Brunner, Hermine I.;Bennett, Michael R.;Mina, Rina;Suzuki, Michiko;Petri, Michelle;Kiani, Adnan N.;Pendl, Joshua;Witte, David;Ying, Jun;Rovin, Brad H.;Devarajan, Prasad
探讨尿生物标志物（UBM）和已建立的肾功能指标（EMRF）与狼疮性肾炎（LN）组织学表现的关系;并测试上述实验室指标的某些组合是否可诊断LN的特定组织学特征。在肾活检后2个月内收集76例患者的尿液样本，并测定UBM：脂质运载蛋白样前列腺素D合成酶（LPGDS）、α1-酸性糖蛋白（AAG）、转铁蛋白（TF）、血浆铜蓝蛋白（CP）、嗜酸性明胶酶相关脂质运载蛋白（NGAL）和单核细胞趋化因子1（MCP 1）。使用非参数分析，将UBM和EMRF水平与LN的组织学特征进行比较：系膜扩张、毛细血管增生、新月体形成、坏死、线环、纤维化、肾小管萎缩和膜外沉积。计算受试者工作特征曲线（AUC）下的面积以预测LN活动性、慢性化或膜性LN。UBM的差异性增加形成了反映活动性LN的特定组织学特征的模式。MCP 1、AAG、CP联合蛋白/肌酐比值对LN活动性的预测效果最好（AUC=0.85）。NGAL+肌酐清除率+MCP 1是诊断LN慢性化和膜性LN的良好指标（AUC=0.83），MCP 1、AAG、肌酐清除率+C4（AUC=0.75）分别是诊断LN慢性化和膜性LN的良好指标。选择UBM与LN活动和慢性观察到的特定组织变化相关。特别是与选择EMRF组合，UBM非常适合于非侵入性地量化LN活性、LN慢性化和膜性LN的存在。
To investigate the relationship of urinary biomarkers (UBM) and established measures of renal function (EMRF) to the histological findings with lupus nephritis (LN); and to test whether certain combinations of the above mentioned laboratory measures are diagnostic of specific histological features of LN. Urine samples of 76 patients were collected within 2 months of a kidney biopsy and assayed for the UBM: lipocalin-like prostaglandin-D synthetase (LPGDS), α1-acid-glycoprotein (AAG), transferrin (TF), ceruloplasmin (CP), neutrophil-gelatinase associated lipocalin (NGAL), and monocyte chemotactic factor 1 (MCP1). Using non-parametric analyses, UBM and EMRF levels were compared to histological features seen with LN: mesangial expansion, capillary proliferation, crescent formation, necrosis, wire loops, fibrosis, tubular atrophy, and epimembranous deposits. The area under the receiver operating characteristic (AUC) curve was calculated to predict LN activity, chronicity or membranous LN. There was a differential increase of the UBM that formed a pattern reflective of specific histological features seen with active LN. The combination of MCP1, AAG, CP plus protein:creatinine ratio were excellent in predicting LN activity (AUC=0.85). NGAL together with creatinine clearance plus MCP1 was an excellent (AUC=0.83) and MCP1, AAG, creatinine clearance plus C4 (AUC=0.75) a good diagnostic test of LN chronicity and membranous LN, respectively. Select UBM are associated with specific tissue changes observed with LN activity and chronicity. Especially in combination with select EMRF, UBM are well-suited to non-invasively quantify LN activity, LN chronicity, and the presence of membranous LN.
登录
查看更多内容
影响因子：
--
作者：
Pawar, Rahul D.;Pitashny, Milena;Gindea, Simona;Tieng, Arlene Tan;Levine, Benjamin;Goilav, Beatrice;Campbell, Sean R.;Xia, Yumin;Qing, Xiaoping;Thomas, David B.;Herlitz, Leal;Berger, Thorsten;Mak, Tak W.;Putterman, Chaim
通讯作者：
Putterman, Chaim
影响因子：
--
作者：
Brunner, Hermine I.;Mueller, Michelle;Devarajan, Prasad
通讯作者：
Devarajan, Prasad
DOI：
10.2215/cjn.04010907
发表时间：
2008-05-01
影响因子：
9.8
作者：
Bennett, Michael;Dent, Catherine L.;Devarajan, Prasad
通讯作者：
Devarajan, Prasad
DOI：
10.2215/cjn.03530708
发表时间：
2009-02-01
影响因子：
9.8
作者：
Bolignano, Davide;Lacquaniti, Antonio;Buemi, Michele
通讯作者：
Buemi, Michele
影响因子：
19.6
作者：
Mezzano, SA;Droguett, MA;Egido, J
通讯作者：
Egido, J