Changes in maternal blood glucose and lipid concentrations during pregnancy differ by maternal body mass index and are related to birthweight: A prospective, longitudinal study of healthy pregnancies
Changes in maternal blood glucose and lipid concentrations during pregnancy differ by maternal body mass index and are related to birthweight: A prospective, longitudinal study of healthy pregnancies
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DOI：
10.1371/journal.pone.0232749
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发表时间：
2020-06-23
期刊：
影响因子：
3.7
通讯作者：
Henriksen, Tore
中科院分区：
文献类型：
--
作者：
Roland, Marie Cecilie Paasche;Lekva, Tove;Henriksen, Tore
背景 世界范围内，孕产妇肥胖正在增加，但其对孕产妇生理和胎儿生长的影响尚不完全清楚。目的 研究正常体重和超重/肥胖妇女妊娠期糖脂代谢变化是否存在差异，并探讨哪些代谢因素与出生体重相关。设计前瞻性、纵向研究。设置奥斯陆大学医院产科，国立医院。人口 1031 名健康单胎孕妇。方法 对妊娠早期和晚期的血样进行空腹血糖、胰岛素和脂质（总胆固醇、HDL-胆固醇、LDL-胆固醇和甘油三酯）分析。通过线性回归模型探讨代谢因素与出生体重（z 分数）之间的关联。主要结果指标：葡萄糖和血脂的组依赖性纵向变化及其与出生体重（z 分数）的关联。结果 与正常体重（BMI < 25）女性相比，超重（BMI 25-29.9）和肥胖（BMI > 30）女性的空腹血糖（4.54、4.68和4.84 mmol/l）、胰岛素（23、33和50 pmol/l）、总胆固醇（4.85、4.99和5.14 mmol/l）、LDL-C显着升高。 （2.49、2.66 和 2.88 mmol/l）和甘油三酯（1.10、1.28 和 1.57 mmol/l），但 HDL-C 较低（1.86、1.75 和 1.55 mmol/l）。 BMI（B 0.05，95% CI 0.03-0.06，p
Background Maternal obesity is increasing worldwide but the consequences for maternal physiology and fetal growth are not fully understood. Objective To study whether changes in glucose and lipid metabolism during pregnancy differ between women with normal weight and overweight/obesity, and investigate which of these metabolic factors are associated with birthweight. Design Prospective, longitudinal study. Setting Department of Obstetrics, Oslo University Hospital, Rikshospitalet. Population 1031 healthy pregnant women with singleton pregnancies. Methods Blood samples from early and late pregnancy were analyzed for fasting glucose, insulin and lipids (total cholesterol, HDL-cholesterol, LDL-cholesterol and triglycerides). Associations between metabolic factors and birthweight (z-scores) were explored by linear regression models. Main Outcome Measures: Group-dependent longitudinal changes in glucose and lipids and their association with birthweight (z-scores). Results Compared to women with normal weight (BMI < 25), women with overweight (BMI 25-29.9) and obesity (BMI > 30) had significantly higher fasting glucose (4.54, 4.68 and 4.84 mmol/l), insulin (23, 33 and 50 pmol/l), total cholesterol (4.85, 4.99 and 5.14 mmol/l), LDL-C (2.49, 2.66 and 2.88 mmol/l) and triglycerides (1.10, 1.28 and 1.57 mmol/l), but lower HDL-C (1.86, 1.75 and 1.55 mmol/l). BMI (B 0.05, 95% CI 0.03-0.06, p