Association of tobacco and alcohol use with earlier development of colorectal cancer: should we modify screening guidelines?
Association of tobacco and alcohol use with earlier development of colorectal cancer: should we modify screening guidelines?
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DOI：
10.1016/j.amjsurg.2008.07.033
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发表时间：
2008-12-01
影响因子：
3
通讯作者：
Mancino, Anne T.
中科院分区：
文献类型：
--
作者：
Acott, Alison A.;Theus, Sue A.;Mancino, Anne T.
背景：目前的指南建议对平均风险患者在50岁时进行初始结直肠癌筛查。酒精和烟草的使用可能与结直肠癌的早期发病有关。我们假设诊断年龄较早和/或更先进的阶段，在患者与这些habits.METHODS：我们查询我们的肿瘤登记处诊断结直肠癌1997年1月至2006年12月。数据进行了分析，以评估酒精和烟草use.Results的影响：335结直肠癌患者，81%使用烟草，51%使用酒精，45%使用两者，14%既不使用。目前吸烟和饮酒与结直肠癌发病年龄较低有关。332例患者中有13例在50岁之前被诊断为结直肠癌。所有人都接触过酒精和烟草。百分之五十四（7/13）的这些患者在34阶段相比，34%的总population.CONCLUSIONS：修改筛选指南，包括这些习惯作为“高风险”因素可能是指。(C)2008年由Elsevier Inc.出版
BACKGROUND: Current guidelines recommend initial colorectal cancer screening at age 50 years for average-risk patients. Alcohol and tobacco use can be associated with earlier onset of colorectal cancer. We hypothesized an earlier age at diagnosis and/or more advanced stage in patients with these habits.METHODS: We queried our tumor registry for colorectal cancer diagnosed between January 1997 and December 2006. Data were analyzed to evaluate effects of alcohol and tobacco use.RESULTS: Of 335 colorectal cancer patients, 81% used tobacco, 51% used alcohol, 45% used both, and 14% used neither. Current tobacco and alcohol use were associated with younger ages at onset of colorectal cancer. Thirteen of 332 patients were diagnosed with colorectal cancer before age 50 years. All had exposure to alcohol and tobacco. Fifty-four percent (7/13) of these patients presented at stage 3/4 compared with 34% of the overall population.CONCLUSIONS: Modification of screening guidelines to include these habits as "high-risk" factors may be indicated. (C) 2008 Published by Elsevier Inc.