Prevention and treatment of functional and structural radiation injury in the rat heart by pentoxifylline and alpha-tocopherol.
Prevention and treatment of functional and structural radiation injury in the rat heart by pentoxifylline and alpha-tocopherol.
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DOI：
10.1016/j.ijrobp.2008.04.042
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发表时间：
2008-09-01
影响因子：
7
通讯作者：
Hauer-Jensen, Martin
中科院分区：
文献类型：
--
作者：
Boerma, Marjan;Roberto, Kerrey A.;Hauer-Jensen, Martin
放射性心脏病（RIHD）是胸部放射治疗的严重副作用。本研究探讨了PTX和α-生育酚对RIHD大鼠模型心脏损伤的影响。雄性Sprague-Dawley大鼠接受分次局部心脏照射，每日剂量为9戈伊，持续5天，照射后观察6个月。大鼠接受戊巴比妥钠（PTX，100 mg/kg/天）和α-生育酚（20 IU/kg/天）联合给药，并从照射前1周至照射后6个月或照射后3个月开始接受这些化合物，在我们的RIHD模型中，组织病理学变化变得明显。PTX和α-生育酚显著降低了放射诱导的左心室舒张压升高（mmHg：假照射后35 ± 6，照射后82 ± 11）（早期治疗：48 ± 7，晚期治疗：53 ± 6）。PTX和α-生育酚显著减少I型胶原沉积（仅辐射：3.5 ± 0.2 μm2/100 μm2，早期治疗：2.7 ± 0.8，晚期治疗：2.2 ± 0.2）和III型胶原沉积（仅辐射：13.9 ± 0.8，早期治疗：11.0 ± 1.2，晚期治疗：10.6 ± 0.8）。另一方面，辐射诱导的心脏/体重比、心肌变性、左心室肥大细胞密度和大多数超声心动图参数的变化未被PTX和α-生育酚显著改变。PTX和α-生育酚治疗对放射诱导的心肌纤维化和左心室离体功能可能具有有益的作用，无论是在放射前开始还是在RIHD过程中稍后开始。
Radiation-induced heart disease (RIHD) is a severe side effect of thoracic radiotherapy. This study examined the effects of PTX and α-tocopherol on cardiac injury in a rat model of RIHD. Male Sprague-Dawley rats received fractionated local heart irradiation with a daily dose of 9 Gy for 5 days and were observed for six months after irradiation. Rats were treated with a combination of pentoxifylline (PTX, 100 mg/kg/day) and α-tocopherol (20 IU/kg/day) and received these compounds either from one week before until six months after irradiation or starting three months after irradiation, a time point at which histopathological changes become apparent in our model of RIHD. Radiation-induced increases in left ventricular diastolic pressure (in mmHg: 35 ± 6 after sham-irradiation, 82 ± 11 after irradiation) were significantly reduced by PTX and α-tocopherol (early treatment: 48 ± 7, late treatment: 53 ± 6). PTX and α-tocopherol significantly reduced deposition of collagen types I (radiation only: 3.5 ± 0.2 μm2 per 100 μm2, early treatment: 2.7 ± 0.8, late treatment: 2.2 ± 0.2) and III (radiation only: 13.9 ± 0.8, early treatment: 11.0 ± 1.2, late treatment: 10.6 ± 0.8). On the other hand, radiation-induced alterations in heart/body weight ratios, myocardial degeneration, left ventricular mast cell densities, and most echocardiographic parameters were not significantly altered by PTX and α-tocopherol. treatment with PTX and α-tocopherol may have beneficial effects on radiation-induced myocardial fibrosis and left ventricular ex vivo function, both when started before irradiation and when started later during the process of RIHD.
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影响因子：
51.1
作者：
Darby, SC;McGale, P;Peto, R
通讯作者：
Peto, R
影响因子：
11.2
作者：
Boerma, M;Wang, JR;Hauer-Jensen, M
通讯作者：
Hauer-Jensen, M
影响因子：
19.6
作者：
Fang, CC;Yen, CJ;Hsieh, BS
通讯作者：
Hsieh, BS
DOI：
10.1016/s0360-3016(02)04601-1
发表时间：
2003-06-01
影响因子：
7
作者：
Vozenin-Brotons, MC;Milliat, F;Aigueperse, J
通讯作者：
Aigueperse, J
影响因子：
13.6
作者：
Lin, SL;Chen, RH;Tsai, TJ
通讯作者：
Tsai, TJ