Is the LDL receptor involved in cortical amyloid protein clearance?
Is the LDL receptor involved in cortical amyloid protein clearance?
复制标题
DOI：
10.1007/s11064-006-9084-0
复制
发表时间：
2006-06-01
影响因子：
4.4
通讯作者：
Hameed, Zeyad
中科院分区：
文献类型：
--
作者：
Abdulkarim, Yasir;Hameed, Zeyad
本文提出低密度脂蛋白受体（LDLR）是参与脑内淀粉样蛋白清除的分子之一，它可能通过他汀类药物上调而在阿尔茨海默病（AD）中发挥作用。该假设基于以下观察结果：a-他汀类药物（已显示可增加星形胶质细胞中的LDLR，见下文）在AD中具有有益作用，在AD中发现LDL受体基因中的b-缺陷，具有与LDLR相似结构的c-分子已显示可从大脑中清除淀粉样蛋白。
This article puts forward the hypothesis that the Low Density Lipid Receptor (LDLR) is one of the molecules that is involved in the clearance of amyloid proteins in the brain and that it may play a role in Alzheimer's Disease (AD) via its up-regulation by statins. The hypothesis is built on the following observations: a-statins (which have been shown to increase LDLR in astrocytes, see below) have a beneficial role in AD, b-defects in the LDL receptor gene are found in AD, c-molecules with similar structure to the LDLR have been shown to clear amyloid protein from the brain.