Elevated serum C-reactive protein levels and early arterial changes in healthy children
Elevated serum C-reactive protein levels and early arterial changes in healthy children
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DOI：
10.1161/01.atv.0000024222.06463.21
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发表时间：
2002-08-01
影响因子：
8.7
通讯作者：
Raitakari, OT
中科院分区：
文献类型：
--
作者：
Järvisalo, MJ;Harmoinen, A;Raitakari, OT
目的：血清c反应蛋白（CRP）浓度升高可预测成人心血管事件。由于动脉粥样硬化始于儿童时期，我们进行了一项研究，以确定健康儿童的臂动脉内皮功能和颈动脉内膜-中膜复合体厚度的变化（早期动脉粥样硬化的两个标志）是否与CRP水平有关。方法与结果：对79例儿童（年龄10.5+/-1.1岁）的肱动脉血流介导扩张（FMD）和颈动脉内膜-中膜厚度（IMT）进行超声测量。与CRP水平低于检出限（0.7 mg/L, n=19，组3）的儿童相比，FMD较低（分别为9.0+/-4.4%对7.8+/-3.3%对6.5+/-2.6%，P=0.015趋势），颈动脉IMT较大（分别为0.45+/-0.03对0.46+/-0.04对0.49+/-0.06 mm， P=0.002趋势）。在多变量分析中，CRP水平仍然是具有统计学意义的肱FMD和颈动脉IMT的独立预测因子。结论：这些数据表明CRP通过干扰内皮功能和促进内膜-中膜增厚来影响健康儿童的动脉。这些发现支持了CRP在早期动脉粥样硬化发病机制中起作用的假设。
Objective-Elevated serum concentration of C-reactive protein (CRP) predicts cardiovascular events in adults. Because atherosclerosis begins in childhood, we undertook a study to determine whether changes in brachial artery endothelial function and the thickness of the carotid intima-media complex, 2 markers of early atherosclerosis, are related to CRP levels in healthy children.Methods and Results-Brachial artery flow-mediated dilatation (FMD) and carotid artery intima-media thickness (IMT) were measured with ultrasound in 79 children (aged 10.5+/-1.1 years). Compared with the children with CRP levels under the detection limit (0.7 mg/L, n=19, group 3) had lower FMD (9.0+/-4.4% versus 7.8+/-3.3% versus 6.5+/-2.6%, respectively; P=0.015 for trend) and greater carotid IMT (0.45+/-0.03 versus 0.46+/-0.04 versus 0.49+/-0.06 mm, respectively, P=0.002 for trend). CRP level remained a statistically significant independent predictor for brachial FMD and carotid IMT in multivariate analyses.Conclusions-These data suggest that CRP affects the arteries of healthy children by disturbing endothelial function and promoting intima-media thickening. The findings support the hypothesis that CRP plays a role in the pathogenesis of early atherosclerosis.