Danger signals in liver injury and restoration of homeostasis.
Danger signals in liver injury and restoration of homeostasis.
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DOI：
10.1016/j.jhep.2020.04.033
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发表时间：
2020-10
影响因子：
25.7
通讯作者：
Nieto N
中科院分区：
文献类型：
--
作者：
Han H;Desert R;Das S;Song Z;Athavale D;Ge X;Nieto N
损伤相关的分子模式是参与炎症反应和恢复稳态的信号分子。这些分子的慢性释放也可以促进肝脏疾病背景下的炎症。在此，我们对损伤相关分子模式作为肝损伤危险信号的作用进行了全面总结。我们认为活性氧和活性氮作为损伤相关分子模式的诱导物的作用，以及特定的损伤相关分子模式如何参与慢性肝病如酒精相关性肝病，非酒精性脂肪性肝炎，肝纤维化和肝癌的发病机制。此外，我们还讨论了损伤相关分子模式在缺血再灌注损伤和肝移植中的作用，并强调了目前的研究，其中特定损伤相关分子模式的阻断已被证明对人类和小鼠有益。
Damage-associated molecular patterns are signalling molecules involved in inflammatory responses and restoration of homeostasis. Chronic release of these molecules can also promote inflammation in the context of liver disease. Herein, we provide a comprehensive summary of the role of damage-associated molecular patterns as danger signals in liver injury. We consider the role of reactive oxygen species and reactive nitrogen species as inducers of damage-associated molecular patterns, as well as how specific damage-associated molecular patterns participate in the pathogenesis of chronic liver diseases such as alcohol-related liver disease, non-alcoholic steatohepatitis, liver fibrosis and liver cancer. In addition, we discuss the role of damage-associated molecular patterns in ischaemia reperfusion injury and liver transplantation and highlight current studies in which blockade of specific damage-associated molecular patterns has proven beneficial in humans and mice.
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影响因子：
--
作者：
Ayala A;Muñoz MF;Argüelles S
通讯作者：
Argüelles S
影响因子：
4.6
作者：
Bijnen M;Beelen N;Wetzels S;Gaar JV;Vroomen M;Wijnands E;Scheijen JL;van de Waarenburg MPH;Gijbels MJ;Cleutjens JP;Biessen EAL;Stehouwer CDA;Schalkwijk CG;Wouters K
通讯作者：
Wouters K
影响因子：
4.4
作者：
Barrientos, Lorena;Bignon, Alexandre;Chollet-Martin, Sylvie
通讯作者：
Chollet-Martin, Sylvie
影响因子：
6
作者：
Cai, Yan;Jogasuria, Alvin;You, Min
通讯作者：
You, Min
DOI：
10.1073/pnas.78.11.6858
发表时间：
1981-01-01
期刊：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES
影响因子：
--
作者：
AMES, BN;CATHCART, R;HOCHSTEIN, P
通讯作者：
HOCHSTEIN, P