A new ligation method for N-terminal tryptophan-containing peptides using the Pictet-Spengler reaction
A new ligation method for N-terminal tryptophan-containing peptides using the Pictet-Spengler reaction
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DOI：
10.1016/s0040-4039(00)00592-x
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发表时间：
2000-05-29
影响因子：
1.8
通讯作者：
Tam, JP
中科院分区：
文献类型：
--
作者：
Li, XF;Zhang, LS;Tam, JP
应用碳碳键形成反应连接无保护肽在醋酸是基于皮塞特-斯宾格勒缩合描述。肽段包括一个在n端有Trp的肽段和另一个在c端有醛的肽段，它们可以通过一种新的环状缩醛树脂生成。(C) 2000 Elsevier Science Ltd.版权所有。
Application of a carbon-carbon bond forming reaction for ligating unprotected peptides in acetic acid is described based on a Pictet-Spengler condensation. The peptide segments include a peptide with a Trp at the N-terminal and another with a C-terminal aldehyde, which can be generated through a new cyclic acetal resin. (C) 2000 Elsevier Science Ltd. All rights reserved.