First total synthesis of 7(S),16(R),17(S)-Resolvin D2, a potent anti-inflammatory lipid mediator
First total synthesis of 7(S),16(R),17(S)-Resolvin D2, a potent anti-inflammatory lipid mediator
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DOI：
10.1016/j.tetlet.2004.09.129
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发表时间：
2004-11-15
影响因子：
1.8
通讯作者：
Spur, BW
中科院分区：
文献类型：
--
作者：
Rodríguez, AR;Spur, BW
首次全合成了二十二碳六烯酸衍生的脂质介质7（S），16（R），17（，S）-Resolvin D2。我们的合成策略的主要特点包括与手性池策略相结合的末端环氧化物的Co-salen水解动力学拆分。(C)2004爱思唯尔有限公司保留所有权利。
The first total synthesis of 7(S), 16(R), 17(,S)-Resolvin D2, a lipid mediator derived from docosahexaenoic acid, has been achieved. The key features of our synthetic strategy encompass a Co-salen hydrolytic kinetic resolution of a terminal epoxide combined with a chiral pool strategy. (C) 2004 Elsevier Ltd. All rights reserved.