Genome editing-induced t(4;11) chromosomal translocations model B cell precursor acute lymphoblastic leukemias with KMT2A-AFF1 fusion.
Genome editing-induced t(4;11) chromosomal translocations model B cell precursor acute lymphoblastic leukemias with KMT2A-AFF1 fusion.
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DOI：
10.1172/jci171030
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发表时间：
2024-01-02
影响因子：
15.9
通讯作者：
Cleary, Michael L.
中科院分区：
文献类型：
--
作者：
Pan, Feng;Sarno, Jolanda;Jeong, Johan;Yang, Xin;Jager, Astraea;Gruber, Tanja A.;Davis, Kara L.;Cleary, Michael L.
A t（4; 11）从KMT 2A和AFF 1基因之间的CRISPR工程化染色体易位建立的白血病模型重现了原发性患者白血病的蛋白质组学、表观基因组学和转录组学特征。
A t(4;11) leukemia model established from CRISPR-engineered chromosomal translocations between the KMT2A and AFF1 genes recapitulate proteomic, epigenomic, and transcriptomic features of primary patient leukemias.