Insulin Receptor of Fat Cells in Insulin-Resistant Metabolic States
Insulin Receptor of Fat Cells in Insulin-Resistant Metabolic States
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胰岛素抵抗代谢状态下脂肪细胞的胰岛素受体
DOI：
10.1126/science.176.4036.805
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发表时间：
1972
期刊：
影响因子：
56.9
通讯作者：
P. Cuatrecasas
中科院分区：
文献类型：
--
作者：
G. V. Bennett;P. Cuatrecasas
对胰岛素的反应减弱表现为从饥饿或用泼尼松治疗或通过给予链脲佐菌素使其患糖尿病的大鼠中获得的分离的脂肪细胞。这种反应的降低并不伴随着这些细胞的胰岛素受体数量的变化或这些受体对胰岛素的亲和力的变化。同样，从某些种属（仓鼠、兔、小鼠、豚鼠）获得的脂肪细胞对胰岛素的反应性降低也不能用胰岛素受体的改变来解释。
A diminished response to insulin is exhibited by isolated fat cells obtained from rats that have been either starved, or treated with prednisone, or made diabetic by administration of streptozotocin. This decrease in response is not accompanied by changes in the quantity of insulin receptor of these cells or in the affinity of these receptors for insulin. Similarly, the decreased responsiveness to insulin of fat cells obtained from certain species (hamster, rabbit, mouse, guinea pig) is not explainable in terms of alterations of the insulin receptor.