Quantitative assessment of amide proton transfer (APT) and nuclear overhauser enhancement (NOE) imaging with extrapolated semisolid magnetization transfer reference (EMR) signals: II. Comparison of three EMR models and application to human brain glioma at 3 Tesla.
Quantitative assessment of amide proton transfer (APT) and nuclear overhauser enhancement (NOE) imaging with extrapolated semisolid magnetization transfer reference (EMR) signals: II. Comparison of three EMR models and application to human brain glioma at 3 Tesla.
复制标题
DOI：
10.1002/mrm.25795
复制
发表时间：
2016-04
影响因子：
3.3
通讯作者：
Zhou J
中科院分区：
文献类型：
--
作者：
Heo HY;Zhang Y;Jiang S;Lee DH;Zhou J
评估使用三种EMR方法来量化人神经胶质瘤中的APT和NOE信号。
将11例高级神经胶质瘤患者在3吨扫描。AEMR2（不对称磁化转移或MT模型以适合双面，广泛的偏移数据），SEMR2（对称MT模型以适合两面，广泛的偏移数据）和SEMR1（对称拟合单方面的较广泛数据的对称MT模型），以3.5 ppm和-3.5 ppm进行了ZEMR，以计算APT和NOE信号（APT＃和noe＃）。
AEMR2和SEMR1模型提供了相似的APT＃信号，而SEMR2提供了较低的APT＃信号。报道的是，与正常组织相比，肿瘤和正常组织的高度高度高。 APT＃映射和NOE＃地图上的略有下降。
SEMR1模型是准确量化APT和NOE信号的最佳选择。 T.
To evaluate the use of three EMR methods to quantify APT and NOE signals in human glioma. Eleven patients with high-grade glioma were scanned at 3 T. aEMR2 (asymmetric magnetization-transfer or MT model to fit two-sided, wide-offset data), sEMR2 (symmetric MT model to fit two-sided, wide-offset data), and sEMR1 (symmetric MT model to fit one-sided, wide-offset data) were assessed. ZEMR and experimental data at 3.5 ppm and −3.5 ppm were subtracted to calculate the APT and NOE signals (APT# and NOE#), respectively. The aEMR2 and sEMR1 models provided quite similar APT# signals, while the sEMR2 provided somewhat lower APT# signals. The aEMR2 had an erroneous NOE# quantification. Calculated APT# signal intensities of glioma (~4%), much larger than the values reported previously, were significantly higher than those of edema and normal tissue. Compared to normal tissue, gadolinium-enhancing tumor cores were consistently hyperintense on the APT# maps and slightly hypointense on the NOE# maps. The sEMR1 model is the best choice for accurately quantifying APT and NOE signals. The APT-weighted hyperintensity in the tumor was dominated by the APT effect, and the MT asymmetry at 3.5 ppm is a reliable and valid metric for APT imaging of gliomas at 3 T.