Prognostic value of genomic alterations in head and neck squamous cell carcinoma detected by comparative genomic hybridisation
Prognostic value of genomic alterations in head and neck squamous cell carcinoma detected by comparative genomic hybridisation
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DOI：
10.1038/sj.bjc.6601199
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发表时间：
2003-09-01
影响因子：
8.8
通讯作者：
Greenman, J
中科院分区：
文献类型：
--
作者：
Ashman, JNE;Patmore, HS;Greenman, J
通过比较基因组杂交分析了总共 45 个原发性头颈鳞状细胞癌，以确定染色体缺失和增加的区域。确定了多个拷贝数畸变区域，包括影响染色体 3q、8q、5p、7q、12p 和 11q 的增加以及染色体 3p、11q、4p、5q、8p、10q、13q 和 21 物质的删除。Kaplan Meier 生存分析显示 3q25 - 27 的增加与 22q 的删除之间存在显着相关性，且疾病特异性降低。生存。此外，17q和20q的增加、19p和22q的缺失以及11q13的扩增与无病生存率的降低显着相关。 Cox 比例风险回归模型将 22q 缺失确定为独立的预后标记。这里提供的数据提供了进一步的证据，表明基于基因的肿瘤分类系统的创建将很快成为可能，补充当前的组织病理学特征。
A total of 45 primary head and neck squamous cell carcinomas were analysed by comparative genomic hybridisation to identify regions of chromosomal deletion and gain. Multiple regions of copy number aberration were identified including gains affecting chromosomes 3q, 8q, 5p, 7q, 12p and 11q and deletion of material from chromosomes 3p, 11q, 4p, 5q, 8p, 10q, 13q and 21. Kaplan Meier survival analysis revealed significant correlations between gain of 3q25 - 27 and deletion of 22q with reduced disease-specific survival. In addition, gain of 17q and 20q, deletion of 19p and 22q and amplification of 11q13 were significantly associated with reduced disease-free survival. A Cox proportional hazards regression model identified deletion of 22q as an independent prognostic marker. The data presented here provide further evidence that the creation of a genetically based tumour classification system will soon be possible, complementing current histopathological characterisation.