Transforming growth factor β‐1 positively modulates the bioactivity of fibroblast growth factor on corneal endothelial cells
Transforming growth factor β‐1 positively modulates the bioactivity of fibroblast growth factor on corneal endothelial cells
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DOI：
10.1002/jcp.1041410221
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发表时间：
1989-11
影响因子：
5.6
通讯作者：
J. Plouët;D. Gospodarowicz
中科院分区：
文献类型：
--
作者：
J. Plouët;D. Gospodarowicz
转化生长因子β - 1 （TGFβ - 1）是体外血管内皮细胞增殖抑制剂，可刺激牛角膜内皮细胞（BCE）增殖。它还能正向调节BCE细胞对成纤维细胞生长因子（FGF）和表皮生长因子（EGF）的反应。这种效应在TGFβ - 1的生理范围内是浓度依赖的，但如果细胞培养在细胞外基质包被的培养皿中而不是塑料培养皿中，这种效应就会被阻断。TGFβ‐1不改变BCE细胞表面bFGF受体的数量或亲和力，但增加了这些细胞的bFGF含量。这表明TGFβ - 1可能通过调节BCE细胞中bFGF的合成而起作用。
Transforming growth factor beta‐1 (TGFβ‐1), known as an inhibitor of vascular endothelial cell proliferation in vitro, stimulates bovine corneal endothelial cells (BCE) proliferation. It also positively modulates the response of BCE cells to fibroblast growth factor (FGF) and epidermal growth factor (EGF). This effect is concentration dependent within a physiological range of TGFβ‐1, but it is blocked if cells are cultured on extracellular‐matrix‐coated dishes instead of plastic. TGFβ‐1 does not modify the number or the affinity of bFGF receptors on BCE cell surface but increases the bFGF content of these cells. This suggests that TGFβ‐1 might act through regulation of bFGF synthesis in BCE cells.