Analyses Focused on Organisms Would Enhance the Value of Detecting Occult Bacteremia
Analyses Focused on Organisms Would Enhance the Value of Detecting Occult Bacteremia
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以生物体为重点的分析将提高检测隐匿性菌血症的价值
DOI：
10.1016/j.jamcollsurg.2021.03.031
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发表时间：
2021
期刊：
影响因子：
--
通讯作者：
Shintaro Yagi
中科院分区：
文献类型：
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作者：
Siyuan Yao;Shintaro Yagi
第三，阐明发展O-BT的潜在危险因素是有价值的。我们同意作者的观点，免疫缺陷可能在OBT患者中起着重要作用，但由于表1没有显示患者背景的任何差异，包括免疫参数，因此手稿中没有数据支持这一假设。只要感染是亚临床的，我们假设内毒素和诱发炎症的数量不那么显著。在正常情况下和免疫功能正常的个体中，根据他们的方案，常规给予广谱抗生素3天可能足以有效治愈OBT。因此，患有O-BT的患者必须具有与O-BT相关的发生SSI的某些特定易感性。
Third, elucidating potential risk factors for developing O-BT is valuable. We agree with the authors that immune deficiency may play an important role in patients with OBT, but no data in the manuscript can support this hypothesis, as Table 1 failed to present any differences in patient background, including immunologic parameters. As long as the infection is subclinical, we assume that the amounts of endotoxin and evoked inflammation are less significant. In a normal situation and in individuals with normal immunologic function, routine administration of broad-spectrum antibiotics for 3 days, according to their protocol, might be effective enough to cure OBT. Therefore, patients with O-BT must have had some specific predispositions for developing SSI in association with O-BT.