Factors associated with glucose tolerance, pre-diabetes, and type 2 diabetes in a rural community of south India: a cross-sectional study
Factors associated with glucose tolerance, pre-diabetes, and type 2 diabetes in a rural community of south India: a cross-sectional study
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DOI：
10.1186/s13098-016-0135-7
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发表时间：
2016-03-08
影响因子：
4.8
通讯作者：
Dewey, Cate
中科院分区：
文献类型：
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作者：
Little, Matthew;Humphries, Sally;Dewey, Cate
背景：过去 25 年里，印度全国农村 2 型糖尿病患病率翻了两番。尽管农村负担日益加重，但很少有研究探讨农村地区假定的危险因素及其与葡萄糖不耐受和糖尿病的关系。我们进行了一项横断面研究，以确定印度南部农村地区空腹血糖受损 (IFG)、糖耐量受损 (IGT) 和 2 型糖尿病的患病率。此外，我们还确定了哪些因素与 2 型糖尿病相关。方法：我们采用随机家庭抽样技术，从 17 个村庄抽取了 2% 的成年人口。每位参与者都填写了一份调查问卷，其中包括基本描述性信息以及对社会经济状况、身体活动和饮食摄入量的评估。测量了身高、体重、腰围和臀围以及血压。口服葡萄糖耐量试验用于确定糖尿病状况。我们使用逐步逻辑模型构建技术来确定几个假定因素与 2 型糖尿病之间的关联。结果：该研究纳入了 753 名参与者。年龄和性别标准化的 IFG 患病率为 3.9%，IGT 患病率为 5.6%，2 型糖尿病患病率为 10.8%。调整混杂因素后与 2 型糖尿病相关的因素包括体力活动 [OR 0.81]、农村地区 [OR 0.76]、多不饱和脂肪摄入量 [OR 0.94]、体重指数 [OR 1.85]、腰臀比 [OR 1.62] 和烟草消费 [OR 2.82]。 结论：我们的研究有助于越来越多的研究表明糖尿病是农村地区的一个重大问题 印度南部。应将相关风险因素视为减轻印度健康负担的潜在目标。
Background: India's national rural prevalence of type 2 diabetes has quadrupled in the past 25 years. Despite the growing rural burden, few studies have examined putative risk factors and their relationship with glucose intolerance and diabetes in rural areas. We undertook a cross-sectional study to determine the prevalence of impaired fasting glucose (IFG), impaired glucose tolerance (IGT), and type 2 diabetes in a rural area of south India. In addition, we determined which factors were associated with type 2 diabetes.Methods: We sampled 2 % of the adult population from 17 villages using a randomized household-level sampling technique. Each participant undertook a questionnaire that included basic descriptive information and an assessment of socioeconomic status, physical activity, and dietary intake. Height, weight, waist and hip circumference, and blood pressure measurements were taken. An oral glucose tolerance test was used to determine diabetes status. We used stepwise logistic model building techniques to determine associations between several putative factors and type 2 diabetes.Results: 753 participants were included in the study. The age- and sex-standardized prevalence of IFG was 3.9 %, IGT was 5.6 %, and type 2 diabetes was 10.8 %. Factors associated with type 2 diabetes after adjusting for confounders included physical activity [OR 0.81], rurality [OR 0.76], polyunsaturated fat intake [OR 0.94], body mass index [OR 1.85], waist to hip ratio [OR 1.62], and tobacco consumption [OR 2.82].Conclusion: Our study contributes to the growing body of research suggesting that diabetes is a significant concern in rural south India. Associated risk factors should be considered as potential targets for reducing health burdens in India.