Anogenital distance in human male and female newborns: a descriptive, cross-sectional study.
Anogenital distance in human male and female newborns: a descriptive, cross-sectional study.
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DOI：
10.1186/1476-069x-3-8
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发表时间：
2004-09-13
期刊：
影响因子：
--
通讯作者：
Hernandez-Avila M
中科院分区：
文献类型：
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作者：
Salazar-Martinez E;Romano-Riquer P;Yanez-Marquez E;Longnecker MP;Hernandez-Avila M
在生殖活性药物作用的动物研究中，肛门生殖器距离（AGD）的测量现在是常规的，并作为胎儿雄激素作用的生物测定。虽然在人类AGD的测量已在文献中讨论，据我们所知，它已正式测量只有两个描述性研究的女性。由于AGD在动物研究中是一种易于测量的敏感结果，因此我们开发并实施了一种人体测量方案，用于测量人类男性和女性的AGD。我们首先评估了20名受试者的AGD措施的可靠性。然后对另外87名新生儿（42名女性，45名男性）进行测量。所有受试者均来自墨西哥的莫雷洛斯。AGD测量的可靠性（Pearson r）为女性0.50，男性0.64。然而，AGD的受试者间变异远大于测量误差引起的变异。男性（平均22 mm）的AGD测量值约为女性（平均11 mm）的两倍，男性和女性的分布几乎没有重叠。人类AGD的性二态性包括初步证据，表明这种结果可能对子宫内暴露于生殖活性药物有反应。
In animal studies of the effects of hormonally active agents, measurement of anogenital distance (AGD) is now routine, and serves as a bioassay of fetal androgen action. Although measurement of AGD in humans has been discussed in the literature, to our knowledge it has been measured formally in only two descriptive studies of females. Because AGD has been an easy-to-measure, sensitive outcome in animals studies, we developed and implemented an anthropometric protocol for measurement of AGD in human males as well as females. We first evaluated the reliability of the AGD measures in 20 subjects. Then measurements were taken on an additional 87 newborns (42 females, 45 males). All subjects were from Morelos, Mexico. The reliability (Pearson r) of the AGD measure was, for females 0.50, and for males, 0.64. The between-subject variation in AGD, however, was much greater than the variation due to measurement error. The AGD measure was about two-fold greater in males (mean, 22 mm) than in females (mean, 11 mm), and there was little overlap in the distributions for males and females. The sexual dimorphism of AGD in humans comprises prima facie evidence that this outcome may respond to in utero exposure to hormonally active agents.