Expression of cancer-associated simple mucin-type O-glycosylated antigens in parasites
Expression of cancer-associated simple mucin-type O-glycosylated antigens in parasites
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DOI：
10.1080/15216540601188553
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发表时间：
2007-01-01
期刊：
影响因子：
4.6
通讯作者：
Osinaga, Eduardo
中科院分区：
文献类型：
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作者：
Osinaga, Eduardo
简单的粘蛋白型 O-聚糖结构，例如 Tn、TF、唾液酸 Tn 和 Tk 抗原，是最特异的人类癌症相关结构之一。这些抗原参与多种类型的受体-配体相互作用，它们是免疫治疗的潜在靶标。在过去的几年中，在属于主要两个蠕虫寄生虫门的不同物种中鉴定出了几种简单的粘蛋白型O-聚糖抗原，并且在克氏锥虫中检测到了带有唾液酸-Tn的糖蛋白。这些结果有利于了解寄生虫糖免疫学的新方面，并可能有助于识别寄生虫的新生物学特征以及宿主与寄生虫的关系。考虑到不同的群体报告某些寄生虫感染与癌症发展之间存在负相关，我们可以假设从寄生虫中获得的简单粘蛋白型 O-糖基化抗原可能是癌症免疫治疗的良好潜在靶标。
Simple mucin-type O-glycan structures, such as Tn, TF, sialyl-Tn and Tk antigens, are among of the most specific human cancer-associated structures. These antigens are involved in several types of receptor-ligand interactions, and they are potential targets for immunotherapy. In the last few years several simple mucin-type O-glycan antigens were identified in different species belonging to the main two helminth parasite phyla, and sialyl-Tn bearing glycoproteins were detected in Trypanosoma cruzi. These results are of interest to understand new aspects in parasite glycoimmunology and may help identify new biological characteristics of parasites as well of the host-parasite relationship. Considering that different groups reported a negative correlation between certain parasite infections and cancer development, we could hypothesize that simple mucin-type O-glycosylated antigens obtained from parasites could be good potential targets for cancer immunotherapy.